Cellular Functions of the ClpP Protease Impacting Bacterial Virulence

Overview

Journal Front Mol Biosci

Specialty Biology

Date 2022 Dec 19

PMID 36533084

Authors

Mazen E Aljghami

Marim M Barghash

Emily Majaesic

Vaibhav Bhandari

Walid A Houry

Affiliations

Soon will be listed here.

Abstract

Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a central AAA+ chaperone-protease complex present in both prokaryotes and eukaryotes that facilitates the unfolding and subsequent degradation of target substrates. ClpX is a hexameric unfoldase ATPase, while ClpP is a tetradecameric serine protease. Substrates of ClpXP belong to many cellular pathways such as DNA damage response, metabolism, and transcriptional regulation. Crucially, disruption of this proteolytic complex in microbes has been shown to impact the virulence and infectivity of various human pathogenic bacteria. Loss of ClpXP impacts stress responses, biofilm formation, and virulence effector protein production, leading to decreased pathogenicity in cell and animal infection models. Here, we provide an overview of the multiple critical functions of ClpXP and its substrates that modulate bacterial virulence with examples from several important human pathogens.

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