The Effects of Bioactive Components from the Rhizome of (Tianma) on the Characteristics of Parkinson's Disease

Overview

Journal Front Pharmacol

Date 2022 Dec 19

PMID 36532787

Authors

Changcheng Lu

Shuhui Qu

Zhangfeng Zhong

Hua Luo

Si San Lei

Hai-Jing Zhong

Huanxing Su

Yitao Wang

Cheong-Meng Chong

Affiliations

Soon will be listed here.

Abstract

Parkinson's disease (PD) is an age-related chronic neurodegenerative disease caused by the death and degeneration of dopaminergic neurons in the substantia nigra of the midbrain. The decrease of the neurotransmitter dopamine in the patient's brain leads to various motor symptoms. PD drugs mainly enhance dopamine levels but cannot prevent or slow down the loss of dopaminergic neurons. In addition, they exhibit significant side effects and addiction issues during long-term use. Therefore, it is particularly urgent to develop novel drugs that have fewer side effects, can improve PD symptoms, and prevent the death of dopaminergic neurons. The rhizome of (Tianma) is a well-known medicinal herb and has long been used as a treatment of nervous system-related diseases in China. Several clinical studies showed that formula comprising Tianma could be used as an add-on therapy for PD patients. Pharmacological studies indicated that Tianma and its bioactive components can reduce the death of dopaminergic neurons, α-synuclein accumulation, and neuroinflammation in various PD models. In this review, we briefly summarize studies regarding the effects of Tianma and its bioactive components' effects on major PD features and explore the potential use of Tianma components for the treatment of PD.

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References

Ke M, Chong C, Zhu Q, Zhang K, Cai C, Lu J . Comprehensive Perspectives on Experimental Models for Parkinson's Disease. Aging Dis. 2021; 12(1):223-246. PMC: 7801282. DOI: 10.14336/AD.2020.0331. View

Harry G . Microglia in Neurodegenerative Events-An Initiator or a Significant Other?. Int J Mol Sci. 2021; 22(11). PMC: 8199265. DOI: 10.3390/ijms22115818. View

Pringsheim T, Jette N, Frolkis A, Steeves T . The prevalence of Parkinson's disease: a systematic review and meta-analysis. Mov Disord. 2014; 29(13):1583-90. DOI: 10.1002/mds.25945. View

Migdalska-Richards A, Schapira A . The relationship between glucocerebrosidase mutations and Parkinson disease. J Neurochem. 2016; 139 Suppl 1:77-90. PMC: 5111601. DOI: 10.1111/jnc.13385. View

Bloem B, Okun M, Klein C . Parkinson's disease. Lancet. 2021; 397(10291):2284-2303. DOI: 10.1016/S0140-6736(21)00218-X. View

Xie H, Hu L, Li G . SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease. Chin Med J (Engl). 2010; 123(8):1086-92. View

Dickson D, Braak H, Duda J, Duyckaerts C, Gasser T, Halliday G . Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol. 2009; 8(12):1150-7. DOI: 10.1016/S1474-4422(09)70238-8. View

. Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol. 2017; 16(11):877-897. PMC: 5641502. DOI: 10.1016/S1474-4422(17)30299-5. View

Kumar H, Kim I, More S, Kim B, Bahk Y, Choi D . Gastrodin protects apoptotic dopaminergic neurons in a toxin-induced Parkinson's disease model. Evid Based Complement Alternat Med. 2013; 2013:514095. PMC: 3603713. DOI: 10.1155/2013/514095. View

10.

Meng F, Guo Z, Hu Y, Mai W, Zhang Z, Zhang B . CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling. Brain. 2019; 142(3):700-718. DOI: 10.1093/brain/awy351. View

11.

Shuchang H, Qiao N, Piye N, Mingwei H, Xiaoshu S, Feng S . Protective effects of gastrodia elata on aluminium-chloride-induced learning impairments and alterations of amino acid neurotransmitter release in adult rats. Restor Neurol Neurosci. 2008; 26(6):467-73. PMC: 2689815. View

12.

Abushouk A, Negida A, Ahmed H, Abdel-Daim M . Neuroprotective mechanisms of plant extracts against MPTP induced neurotoxicity: Future applications in Parkinson's disease. Biomed Pharmacother. 2016; 85:635-645. DOI: 10.1016/j.biopha.2016.11.074. View

13.

Zhan H, Zhou H, Sui Y, Du X, Wang W, Dai L . The rhizome of Gastrodia elata Blume - An ethnopharmacological review. J Ethnopharmacol. 2016; 189:361-85. DOI: 10.1016/j.jep.2016.06.057. View

14.

Lin S, Tsai Y, Lai J, Wu C . Demographic and medication characteristics of traditional Chinese medicine users among dementia patients in Taiwan: a nationwide database study. J Ethnopharmacol. 2014; 161:108-15. DOI: 10.1016/j.jep.2014.12.015. View

15.

Doo A, Kim S, Hahm D, Hyun Yoo H, Park J, Lee H . Gastrodia elata Blume alleviates L-DOPA-induced dyskinesia by normalizing FosB and ERK activation in a 6-OHDA-lesioned Parkinson's disease mouse model. BMC Complement Altern Med. 2014; 14:107. PMC: 3994477. DOI: 10.1186/1472-6882-14-107. View

16.

Lu K, Ou G, Chang H, Chen W, Liu S, Sheen L . Safety evaluation of water extract of Gastrodia elata Blume: Genotoxicity and 28-day oral toxicity studies. Regul Toxicol Pharmacol. 2020; 114:104657. DOI: 10.1016/j.yrtph.2020.104657. View

17.

Gonzalez-Rodriguez P, Zampese E, Stout K, Guzman J, Ilijic E, Yang B . Disruption of mitochondrial complex I induces progressive parkinsonism. Nature. 2021; 599(7886):650-656. PMC: 9189968. DOI: 10.1038/s41586-021-04059-0. View

18.

Dai J, Zong Y, Zhong L, Li Y, Zhang W, Bian L . Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. PLoS One. 2011; 6(7):e21891. PMC: 3134470. DOI: 10.1371/journal.pone.0021891. View

19.

Dionisio P, Amaral J, Rodrigues C . Oxidative stress and regulated cell death in Parkinson's disease. Ageing Res Rev. 2021; 67:101263. DOI: 10.1016/j.arr.2021.101263. View

20.

Jiang G, Hu Y, Liu L, Cai J, Peng C, Li Q . Gastrodin protects against MPP(+)-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK/Nrf2 pathway in human dopaminergic cells. Neurochem Int. 2014; 75:79-88. DOI: 10.1016/j.neuint.2014.06.003. View