The Interplay Between Cardiac Dyads and Mitochondria Regulated the Calcium Handling in Cardiomyocytes

Overview

Journal Front Physiol

Date 2022 Dec 19

PMID 36531185

Authors

Lei Liu

Kaiyu Zhou

Xiaoliang Liu

Yimin Hua

Hua Wang

Yifei Li

Affiliations

Soon will be listed here.

Abstract

Calcium mishandling and mitochondrial dysfunction have been increasingly recognized as significant factors involved in the progression procedure of cardiomyopathy. Ca2+ mishandling could cause calcium-triggered arrhythmias, which could enhance force development and ATP consumption. Mitochondrial disorganization and dysfunction in cardiomyopathy could disturb the balance of energy catabolic and anabolic procedure. Close spatial localization and arrangement of structural among T-tubule, sarcoplasmic reticulum, mitochondria are important for Ca2+ handling. So that, we illustrate the regulating network between calcium handling and mitochondrial homeostasis, as well as its intracellular mechanisms in this review, which would be worthy to develop novel therapeutic strategy and restore the function of injured cardiomyocytes.

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