Regulation of Epithelial-mesenchymal Transition by Tumor Microenvironmental Signals and Its Implication in Cancer Therapeutics

Overview

Journal Semin Cancer Biol

Specialty Oncology

Date 2022 Dec 15

PMID 36521737

Authors

Jing Zhang

Zhimin Hu

Calista A Horta

Jing Yang

Affiliations

Soon will be listed here.

Abstract

Epithelial-mesenchymal transition (EMT) has been implicated in various aspects of tumor development, including tumor invasion and metastasis, cancer stemness, and therapy resistance. Diverse stroma cell types along with biochemical and biophysical factors in the tumor microenvironment impinge on the EMT program to impact tumor progression. Here we provide an in-depth review of various tumor microenvironmental signals that regulate EMT in cancer. We discuss the molecular mechanisms underlying the role of EMT in therapy resistance and highlight new therapeutic approaches targeting the tumor microenvironment to impact EMT and tumor progression.

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