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The Electrocardiogram in the Assessment of the Effect of Drugs on Cardiac Arrhythmias

Overview
Specialty Pharmacology
Date 1978 Dec 1
PMID 365208
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Abstract

The search for the ideal antiarrhythmic drug continues since none of the available agents offers optimum antiarrhythmic therapy. The continuing search coupled with the interest in the mechanisms of cardiac arrhythmias has led to the development of new techniques for the study of arrhythmias and antiarrhythmic drugs. In this article it is proposed to discuss the electrocardiographic methods used in the assessment of antiarrhythmic drugs. Firstly, to discuss the electrocardiogram in the assessment of the clinical electrophysiological properties of a drug and secondly, the electrocardiogram in the assessment of the value of the drug in the management of cardiac arrhythmias in man.

References
1.
Giardina E, BIGGER Jr J . Procaine amide against re-entrant ventricular arrhythmias. Lengthening R-V intervals of coupled ventricular premature depolarization as an insight into the mechanism of action of procaine amide. Circulation. 1973; 48(5):959-70. DOI: 10.1161/01.cir.48.5.959. View

2.
BIGGER Jr J, Schmidt D, KUTT H . Relationship between the plasma level of diphenylhydantoin sodium and its cardiac antiarrhythmic effects. Circulation. 1968; 38(2):363-74. DOI: 10.1161/01.cir.38.2.363. View

3.
Narula O, SAMET P, Javier R . Significance of the sinus-node recovery time. Circulation. 1972; 45(1):140-58. DOI: 10.1161/01.cir.45.1.140. View

4.
LOWN B, Wolf M . Approaches to sudden death from coronary heart disease. Circulation. 1971; 44(1):130-42. DOI: 10.1161/01.cir.44.1.130. View

5.
Jelinek M, LOWN B . Exercise stress testing for exposure of cardiac arrhythmia. Prog Cardiovasc Dis. 1974; 16(5):497-522. DOI: 10.1016/0033-0620(74)90008-5. View