Five-year Changes in Alcohol Intake and Risk of Atrial Fibrillation: a Danish Cohort Study

Overview

Journal Eur J Prev Cardiol

Publisher Oxford University Press

Specialty Cardiology & Vascular Diseases

Date 2022 Dec 12

PMID 36508613

Authors

Tanja Charlotte Frederiksen

Morten Krogh Christiansen

Emelia J Benjamin

Kim Overvad

Anja Olsen

Christina Catherine Dahm

Henrik Kjaerulf Jensen

Affiliations

Soon will be listed here.

Abstract

Aims: Alcohol intake is a well-established risk factor for atrial fibrillation (AF). However, evidence on the effects of changes in alcohol intake to primary AF prevention is sparse. The aim of this study was to examine the association between 5-year changes in alcohol intake and the risk of incident AF.

Methods And Results: This study was based on the Danish cohort study Diet, Cancer and Health. Lifestyle factors were assessed using questionnaires at a recruitment research examination and a second examination 5 years later. Diagnoses of AF and comorbidities were retrieved from the Danish National Patient Registry. 43 758 participants without prior AF were included. The median age was 61 (25th-75th percentile 58-66) years and 54% were female. Over a median follow-up time of 15.7 years, 5312 participants had incident AF (incidence rate 8.6/1000 person-years). Compared with stable intake, increases in alcohol intake to ≥21 drinks/week from ≤6.9 drinks/week (HR: 1.38, 95% CI: 1.09-1.72) or 14-20.9 drinks/week (HR: 1.27, 95% CI: 1.01-1.59) at baseline were associated with a higher risk of AF. In contrast, we did not observe a statistically significant association between reductions in alcohol intake and the risk of AF.

Conclusion: A 5-year increase in alcohol intake was associated with a greater risk of AF compared with a stable low/moderate intake.

Citing Articles

The association between alcohol intake and incident atrial fibrillation in older adults: The ARIC cohort.

Li L, Li L, Chen L, Soliman E, Alonso A PLoS One. 2024; 19(11):e0314207.

PMID: 39570908 PMC: 11581337. DOI: 10.1371/journal.pone.0314207.

Dietary interventions in the management of atrial fibrillation.

Nabil M, Rychlik L, Nicholson A, Cheung P, Olsovsky G, Molden J Front Cardiovasc Med. 2024; 11:1418059.

PMID: 39149585 PMC: 11324562. DOI: 10.3389/fcvm.2024.1418059.

Alcohol and Atrial Fibrillation.

Surma S, Lip G Rev Cardiovasc Med. 2024; 24(3):73.

PMID: 39077490 PMC: 11264018. DOI: 10.31083/j.rcm2403073.

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