Efficacy and Safety of Intermittent Fasting in People With Insulin-Treated Type 2 Diabetes (INTERFAST-2)-A Randomized Controlled Trial

Overview

Journal Diabetes Care

Specialty Endocrinology

Date 2022 Dec 12

PMID 36508320

Authors

Anna Obermayer

Norbert J Tripolt

Peter N Pferschy

Harald Kojzar

Faisal Aziz

Alexander Muller

Markus Schauer

Abderrahim Oulhaj

Felix Aberer

Caren Sourij

Hansjorg Habisch

Tobias Madl

Thomas Pieber

Barbara Obermayer-Pietsch

Vanessa Stadlbauer

Harald Sourij

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the safety and feasibility of 3 nonconsecutive days of intermittent fasting (IF) per week over 12 weeks in participants with insulin-treated type 2 diabetes.

Research Design And Methods: Forty-six people were randomized to an IF or control group. Dietary counseling and continuous glucose monitoring was provided. Coprimary end points were the change in HbA1c from baseline to 12 weeks and a composite end point (weight reduction ≥2%, insulin dose reduction ≥10%, and HbA1c reduction ≥3 mmol/mol).

Results: The IF group showed a significant HbA1c reduction (-7.3 ± 12.0 mmol/mol) compared with the control group (0.1 ± 6.1 mmol/mol) over 12 weeks (P = 0.012). The coprimary end point was achieved by 8 people in the IF and none in the control group (P < 0.001). No severe hypoglycemia occurred.

Conclusions: IF is a safe and feasible dietary option to ameliorate glycemic control while reducing total daily insulin dose and body weight in insulin-treated people with type 2 diabetes.

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