Matricellular Proteins in Cutaneous Wound Healing

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Dec 12

PMID 36506087

Authors

Claudia Griselda Cardenas-Leon

Kristina Maemets-Allas

Mariliis Klaas

Heli Lagus

Esko Kankuri

Viljar Jaks

Affiliations

Soon will be listed here.

Abstract

Cutaneous wound healing is a complex process that encompasses alterations in all aspects of the skin including the extracellular matrix (ECM). ECM consist of large structural proteins such as collagens and elastin as well as smaller proteins with mainly regulative properties called matricellular proteins. Matricellular proteins bind to structural proteins and their functions include but are not limited to interaction with cell surface receptors, cytokines, or protease and evoking a cellular response. The signaling initiated by matricellular proteins modulates differentiation and proliferation of cells having an impact on the tissue regeneration. In this review we give an overview of the matricellular proteins that have been found to be involved in cutaneous wound healing and summarize the information known to date about their functions in this process.

Citing Articles

Ethanolic Extract Enhances Wound Healing by Modulating FAK/Src/Akt/p38 and Rac1 Signaling in Keratinocytes HaCaT Cells.

Moolsup F, Sukketsiri W, Sianglum W, Saetan J, Khumpirapang N, Tanasawet S Adv Pharmacol Pharm Sci. 2025; 2025:7198281.

PMID: 39886257 PMC: 11779993. DOI: 10.1155/adpp/7198281.

Matrix-Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation Through Increased Nuclear Deformation and Chromatin Accessibility.

Shin S, Bayarkhangai B, Tsogtbaatar K, Yuxuan M, Kim S, Kim Y Adv Sci (Weinh). 2025; 12(8):e2403409.

PMID: 39828979 PMC: 11848612. DOI: 10.1002/advs.202403409.

Matricellular proteins: Potential biomarkers in head and neck cancer.

Wang Y, Liu X, Wang X, Lu J, Tian Y, Liu Q J Cell Commun Signal. 2024; 18(2):e12027.

PMID: 38946720 PMC: 11208127. DOI: 10.1002/ccs3.12027.

Involvement of Matricellular Proteins in Cellular Senescence: Potential Therapeutic Targets for Age-Related Diseases.

Fujita M, Sasada M, Iyoda T, Fukai F Int J Mol Sci. 2024; 25(12).

PMID: 38928297 PMC: 11204155. DOI: 10.3390/ijms25126591.

Electrospun Nanofiber Scaffolds Loaded with Metal-Based Nanoparticles for Wound Healing.

Dang Z, Ma X, Yang Z, Wen X, Zhao P Polymers (Basel). 2024; 16(1).

PMID: 38201687 PMC: 10780332. DOI: 10.3390/polym16010024.

References

Guette C, Valo I, Vetillard A, Coqueret O . Olfactomedin-4 is a candidate biomarker of solid gastric, colorectal, pancreatic, head and neck, and prostate cancers. Proteomics Clin Appl. 2014; 9(1-2):58-63. DOI: 10.1002/prca.201400083. View

Camacho D, Jesus J, Palma A, Martins S, Afonso A, Peixoto M . SPARC-p53: The double agents of cancer. Adv Cancer Res. 2020; 148:171-199. DOI: 10.1016/bs.acr.2020.05.004. View

Zhang C, Hu C, Su K, Wang K, Du X, Xing B . The Integrative Analysis of Thrombospondin Family Genes in Pan-Cancer Reveals that THBS2 Facilitates Gastrointestinal Cancer Metastasis. J Oncol. 2021; 2021:4405491. PMC: 8598331. DOI: 10.1155/2021/4405491. View

Vitobello A, Mazel B, Lelianova V, Zangrandi A, Petitto E, Suckling J . ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model. Am J Hum Genet. 2022; 109(8):1436-1457. PMC: 9388395. DOI: 10.1016/j.ajhg.2022.06.011. View

Sundaramurthi D, Vasanthan K, Kuppan P, Krishnan U, Sethuraman S . Electrospun nanostructured chitosan-poly(vinyl alcohol) scaffolds: a biomimetic extracellular matrix as dermal substitute. Biomed Mater. 2012; 7(4):045005. DOI: 10.1088/1748-6041/7/4/045005. View

Lin Y, Chen J, Wu M, Hsieh I, Liang C, Hsu C . Galectin-1 accelerates wound healing by regulating the neuropilin-1/Smad3/NOX4 pathway and ROS production in myofibroblasts. J Invest Dermatol. 2014; 135(1):258-268. DOI: 10.1038/jid.2014.288. View

Bornstein P . Matricellular proteins: an overview. J Cell Commun Signal. 2009; 3(3-4):163-5. PMC: 2778588. DOI: 10.1007/s12079-009-0069-z. View

Stalin J, Imhof B, Coquoz O, Jeitziner R, Hammel P, McKee T . Targeting OLFML3 in Colorectal Cancer Suppresses Tumor Growth and Angiogenesis, and Increases the Efficacy of Anti-PD1 Based Immunotherapy. Cancers (Basel). 2021; 13(18). PMC: 8464773. DOI: 10.3390/cancers13184625. View

Inomata H, Haraguchi T, Sasai Y . Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation. Cell. 2008; 134(5):854-65. DOI: 10.1016/j.cell.2008.07.008. View

10.

Tang S, Wang T, Zhang X, Guo Y, Xu P, Zeng J . Olfactomedin-3 Enhances Seizure Activity by Interacting With AMPA Receptors in Epilepsy Models. Front Cell Dev Biol. 2020; 8:722. PMC: 7431667. DOI: 10.3389/fcell.2020.00722. View

11.

Rousselle P, Montmasson M, Garnier C . Extracellular matrix contribution to skin wound re-epithelialization. Matrix Biol. 2018; 75-76:12-26. DOI: 10.1016/j.matbio.2018.01.002. View

12.

Longmate W, Monichan R, Chu M, Tsuda T, Mahoney M, DiPersio C . Reduced fibulin-2 contributes to loss of basement membrane integrity and skin blistering in mice lacking integrin α3β1 in the epidermis. J Invest Dermatol. 2014; 134(6):1609-1617. PMC: 4020984. DOI: 10.1038/jid.2014.10. View

13.

Redfern C, Degtyarev M, Kwa A, Salomonis N, COTTE N, Nanevicz T . Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proc Natl Acad Sci U S A. 2000; 97(9):4826-31. PMC: 18317. DOI: 10.1073/pnas.97.9.4826. View

14.

Perbal B . CCN proteins: multifunctional signalling regulators. Lancet. 2004; 363(9402):62-4. DOI: 10.1016/S0140-6736(03)15172-0. View

15.

Riser B, Barnes J, Varani J . Balanced regulation of the CCN family of matricellular proteins: a novel approach to the prevention and treatment of fibrosis and cancer. J Cell Commun Signal. 2015; 9(4):327-39. PMC: 4715828. DOI: 10.1007/s12079-015-0309-3. View

16.

Bornstein P . Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1. J Cell Biol. 1995; 130(3):503-6. PMC: 2120533. DOI: 10.1083/jcb.130.3.503. View

17.

Nakaya N, Sultana A, Lee H, Tomarev S . Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth. J Biol Chem. 2012; 287(44):37171-84. PMC: 3481317. DOI: 10.1074/jbc.M112.389916. View

18.

Zeng L, Han Z, Ma W . Elucidation of subfamily segregation and intramolecular coevolution of the olfactomedin-like proteins by comprehensive phylogenetic analysis and gene expression pattern assessment. FEBS Lett. 2005; 579(25):5443-53. DOI: 10.1016/j.febslet.2005.08.064. View

19.

Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanemura A . Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts. Exp Dermatol. 2012; 21(5):331-6. DOI: 10.1111/j.1600-0625.2012.01454.x. View

20.

Gonzalez-Gonzalez L, Alonso J . Periostin: A Matricellular Protein With Multiple Functions in Cancer Development and Progression. Front Oncol. 2018; 8:225. PMC: 6005831. DOI: 10.3389/fonc.2018.00225. View