Assessing the Effects of Dietary Protein Supplementation on Sarcopenia in Community-Dwelling Older Adults

Overview

Journal Can Geriatr J

Specialty Geriatrics

Date 2022 Dec 12

PMID 36505918

Authors

Vincent Hou

Kenneth Madden

Affiliations

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Abstract

Sarcopenia, an age-associated skeletal muscle disorder characterized by muscle loss, is associated with disability in elderly populations. This literature review summarizes the impact of protein intake and supplementation on the indicators of severe sarcopenia-muscle mass, muscle strength, and physical function in community-dwelling older adults. We performed a literature search on PubMed, EMBASE, and MedLine, and included studies that evaluated the effects of protein intake with or without exercise intervention and on sarcopenia in community-dwelling older adults. Information regarding study participants, protein intervention, and sarcopenia-related outcomes were collected. Protein supplementation with or without exercise positively improves muscle mass, and aspects of muscle strength and physical function in sarcopenic and pre-frail older adults, while it elicited inconclusive effects in healthy populations. Greater dietary animal-based and soy-based protein diets can improve muscle mass in older adults. In conclusion, protein supplementation can improve muscle mass and reduce the risk of sarcopenia in sarcopenia and pre-frail older adults, while future studies should continue to investigate the effects of protein supplementation on indicators of sarcopenia in healthy older adults.

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References

Beasley J, Shikany J, Thomson C . The role of dietary protein intake in the prevention of sarcopenia of aging. Nutr Clin Pract. 2013; 28(6):684-90. PMC: 3928027. DOI: 10.1177/0884533613507607. View

Wilkinson D, Piasecki M, Atherton P . The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans. Ageing Res Rev. 2018; 47:123-132. PMC: 6202460. DOI: 10.1016/j.arr.2018.07.005. View

Degens H . The role of systemic inflammation in age-related muscle weakness and wasting. Scand J Med Sci Sports. 2009; 20(1):28-38. DOI: 10.1111/j.1600-0838.2009.01018.x. View

Yoo S, No M, Heo J, Park D, Kang J, Kim S . Role of exercise in age-related sarcopenia. J Exerc Rehabil. 2018; 14(4):551-558. PMC: 6165967. DOI: 10.12965/jer.1836268.134. View

Trumbo P, Schlicker S, Yates A, Poos M . Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J Am Diet Assoc. 2002; 102(11):1621-30. DOI: 10.1016/s0002-8223(02)90346-9. View

Kim H, Kim M, Kojima N, Fujino K, Hosoi E, Kobayashi H . Exercise and Nutritional Supplementation on Community-Dwelling Elderly Japanese Women With Sarcopenic Obesity: A Randomized Controlled Trial. J Am Med Dir Assoc. 2016; 17(11):1011-1019. DOI: 10.1016/j.jamda.2016.06.016. View

Chanet A, Verlaan S, Salles J, Giraudet C, Patrac V, Pidou V . Supplementing Breakfast with a Vitamin D and Leucine-Enriched Whey Protein Medical Nutrition Drink Enhances Postprandial Muscle Protein Synthesis and Muscle Mass in Healthy Older Men. J Nutr. 2017; 147(12):2262-2271. DOI: 10.3945/jn.117.252510. View

Kirk B, Mooney K, Amirabdollahian F, Khaiyat O . Exercise and Dietary-Protein as a Countermeasure to Skeletal Muscle Weakness: Liverpool Hope University - Sarcopenia Aging Trial (LHU-SAT). Front Physiol. 2019; 10:445. PMC: 6524700. DOI: 10.3389/fphys.2019.00445. View

Mijnarends D, Koster A, Schols J, Meijers J, Halfens R, Gudnason V . Physical activity and incidence of sarcopenia: the population-based AGES-Reykjavik Study. Age Ageing. 2016; 45(5):614-20. PMC: 5027639. DOI: 10.1093/ageing/afw090. View

10.

Fried L, Tangen C, Walston J, Newman A, Hirsch C, Gottdiener J . Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56(3):M146-56. DOI: 10.1093/gerona/56.3.m146. View

11.

Rondanelli M, Faliva M, Monteferrario F, Peroni G, Repaci E, Allieri F . Novel insights on nutrient management of sarcopenia in elderly. Biomed Res Int. 2015; 2015:524948. PMC: 4326274. DOI: 10.1155/2015/524948. View

12.

Nilsson M, Mikhail A, Lan L, Di Carlo A, Hamilton B, Barnard K . A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly. Nutrients. 2020; 12(8). PMC: 7468764. DOI: 10.3390/nu12082391. View

13.

Mori H, Tokuda Y . Effect of whey protein supplementation after resistance exercise on the muscle mass and physical function of healthy older women: A randomized controlled trial. Geriatr Gerontol Int. 2018; 18(9):1398-1404. DOI: 10.1111/ggi.13499. View

14.

Yamamoto Y, Nagai Y, Kawanabe S, Hishida Y, Hiraki K, Sone M . Effects of resistance training using elastic bands on muscle strength with or without a leucine supplement for 48 weeks in elderly patients with type 2 diabetes. Endocr J. 2020; 68(3):291-298. DOI: 10.1507/endocrj.EJ20-0550. View

15.

Taylor D . Physical activity is medicine for older adults. Postgrad Med J. 2013; 90(1059):26-32. PMC: 3888599. DOI: 10.1136/postgradmedj-2012-131366. View

16.

Ellis A, Hunter G, Goss A, Gower B . Oral Supplementation with Beta-Hydroxy-Beta-Methylbutyrate, Arginine, and Glutamine Improves Lean Body Mass in Healthy Older Adults. J Diet Suppl. 2018; 16(3):281-293. PMC: 6314919. DOI: 10.1080/19390211.2018.1454568. View

17.

Hairi N, Cumming R, Naganathan V, Handelsman D, Le Couteur D, Creasey H . Loss of muscle strength, mass (sarcopenia), and quality (specific force) and its relationship with functional limitation and physical disability: the Concord Health and Ageing in Men Project. J Am Geriatr Soc. 2010; 58(11):2055-62. DOI: 10.1111/j.1532-5415.2010.03145.x. View

18.

Steffl M, Bohannon R, Sontakova L, Tufano J, Shiells K, Holmerova I . Relationship between sarcopenia and physical activity in older people: a systematic review and meta-analysis. Clin Interv Aging. 2017; 12:835-845. PMC: 5441519. DOI: 10.2147/CIA.S132940. View

19.

Zhu K, Kerr D, Meng X, Devine A, Solah V, Binns C . Two-Year Whey Protein Supplementation Did Not Enhance Muscle Mass and Physical Function in Well-Nourished Healthy Older Postmenopausal Women. J Nutr. 2015; 145(11):2520-6. DOI: 10.3945/jn.115.218297. View

20.

Yanai H . Nutrition for Sarcopenia. J Clin Med Res. 2015; 7(12):926-31. PMC: 4625812. DOI: 10.14740/jocmr2361w. View