Case Report: Severe Acute Hepatitis in a 22-month-old Chinese Boy with Omicron Sub-variant BA.2.38

Overview

Journal Front Public Health

Specialty Public Health

Date 2022 Dec 12

PMID 36504992

Authors

Xinying Chen

Junbin Hong

Yuxia Li

Caixia An

Jianwen Guo

Jinghua Yang

Affiliations

Soon will be listed here.

Abstract

The etiology of severe acute hepatitis (SAH) in children is various. We describe the first Chinese case of severe acute hepatitis in a 22-month-old boy with the mild illness of Omicron sub-variant BA.2.38. With the application of Compound Glycyrrhizin Injection (CGI), the patient gradually recovered from acute liver injury (ALI). This case highlights the possibility of severe ALI in children with the non-critical illness of SARS-CoV-2. The management of SAH associated with the pandemic presents challenges for clinicians, and follow-up is in need. The method of differential diagnosis using limited laboratory results is of great value to the clinicians.

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References

Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W . A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798):270-273. PMC: 7095418. DOI: 10.1038/s41586-020-2012-7. View

Case S, Son M . COVID-19 in Pediatrics. Rheum Dis Clin North Am. 2021; 47(4):797-811. PMC: 8292034. DOI: 10.1016/j.rdc.2021.07.006. View

Del Zompo F, De Siena M, Ianiro G, Gasbarrini A, Pompili M, Ponziani F . Prevalence of liver injury and correlation with clinical outcomes in patients with COVID-19: systematic review with meta-analysis. Eur Rev Med Pharmacol Sci. 2020; 24(24):13072-13088. DOI: 10.26355/eurrev_202012_24215. View

Giannattasio A, Maglione M, DAnna C, Muzzica S, Pappacoda S, Lenta S . Liver and Pancreatic Involvement in Children with Multisystem Inflammatory Syndrome Related to SARS-CoV-2: A Monocentric Study. Children (Basel). 2022; 9(4). PMC: 9029098. DOI: 10.3390/children9040575. View

Phipps M, Barraza L, LaSota E, Sobieszczyk M, Pereira M, Zheng E . Acute Liver Injury in COVID-19: Prevalence and Association with Clinical Outcomes in a Large U.S. Cohort. Hepatology. 2020; 72(3):807-817. PMC: 7300739. DOI: 10.1002/hep.31404. View

McCormick D, Richardson L, Young P, Viens L, Gould C, Kimball A . Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States. Pediatrics. 2021; 148(5). PMC: 9837742. DOI: 10.1542/peds.2021-052273. View

Oualha M, Bendavid M, Berteloot L, Corsia A, Lesage F, Vedrenne M . Severe and fatal forms of COVID-19 in children. Arch Pediatr. 2020; 27(5):235-238. PMC: 7269941. DOI: 10.1016/j.arcped.2020.05.010. View

Cooper S, Tobar A, Konen O, Orenstein N, Gilad N, Landau Y . Long COVID-19 Liver Manifestation in Children. J Pediatr Gastroenterol Nutr. 2022; 75(3):244-251. DOI: 10.1097/MPG.0000000000003521. View

Pirisi M, Rigamonti C, DAlfonso S, Nebuloni M, Fanni D, Gerosa C . Liver infection and COVID-19: the electron microscopy proof and revision of the literature. Eur Rev Med Pharmacol Sci. 2021; 25(4):2146-2151. DOI: 10.26355/eurrev_202102_25120. View

10.

Sgouropoulou V, Vargiami E, Kyriazi M, Papadimitriou E, Agakidis C, Zafeiriou D . Transient Severe Liver Injury: A Unique Presentation of COVID-19 Disease in a Pediatric Patient. Pediatr Infect Dis J. 2021; 40(5):e204-e205. DOI: 10.1097/INF.0000000000003104. View

11.

Khader S, Foster I, Dagens A, Norton A, Sigfrid L . Severe acute hepatitis of unknown aetiology in children-what is known?. BMC Med. 2022; 20(1):280. PMC: 9336128. DOI: 10.1186/s12916-022-02471-5. View

12.

Wang Y, Liu S, Liu H, Li W, Lin F, Jiang L . SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19. J Hepatol. 2020; 73(4):807-816. PMC: 7211738. DOI: 10.1016/j.jhep.2020.05.002. View

13.

Yang R, Zheng R, Fan J . Etiology and management of liver injury in patients with COVID-19. World J Gastroenterol. 2020; 26(32):4753-4762. PMC: 7459209. DOI: 10.3748/wjg.v26.i32.4753. View

14.

Zhou Y, Zheng K, Targher G, Byrne C, Zheng M . Abnormal liver enzymes in children and infants with COVID-19: A narrative review of case-series studies. Pediatr Obes. 2020; 15(12):e12723. DOI: 10.1111/ijpo.12723. View

15.

Cevik M, Rasmussen A, Bogoch I, Kindrachuk J . Acute hepatitis of unknown origin in children. BMJ. 2022; 377:o1197. DOI: 10.1136/bmj.o1197. View

16.

Antala S, Diamond T, Kociolek L, Shah A, Chapin C . Severe Hepatitis in Pediatric Coronavirus Disease 2019. J Pediatr Gastroenterol Nutr. 2022; 74(5):631-635. PMC: 9117453. DOI: 10.1097/MPG.0000000000003404. View

17.

Palpacelli A, Martelli G, Lattanzi B, Volpini A, Cazzato S . Severe hypertransaminasemia during mild SARS-CoV-2 infection: A pediatric case report and literature review. Pediatr Investig. 2021; 5(4):310-312. PMC: 8662248. DOI: 10.1002/ped4.12300. View

18.

Swann O, Holden K, Turtle L, Pollock L, Fairfield C, Drake T . Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ. 2020; 370:m3249. PMC: 7488201. DOI: 10.1136/bmj.m3249. View

19.

Mao R, Qiu Y, He J, Tan J, Li X, Liang J . Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2020; 5(7):667-678. PMC: 7217643. DOI: 10.1016/S2468-1253(20)30126-6. View

20.

Sun J, Aghemo A, Forner A, Valenti L . COVID-19 and liver disease. Liver Int. 2020; 40(6):1278-1281. DOI: 10.1111/liv.14470. View