ACE-Vitamin Index and Risk of Glaucoma: The SUN Project

Overview

Journal Nutrients

Date 2022 Dec 11

PMID 36501162

Authors

Javier Moreno-Montanes

Elsa Gandara

Laura Moreno-Galarraga

Maria S Hershey

Jose Francisco Lopez-Gil

Stefanos Kales

Maira Bes-Rastrollo

Miguel Angel Martinez-Gonzalez

Alejandro Fernandez-Montero

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies regarding antioxidant consumption and glaucoma have shown contradictory results. The aim of this study was to analyze the combined effect of the consumption of three vitamins (A, C and E) on the incidence of glaucoma in the SUN Project.

Methods: For this study, 18,669 participants were included. The mean follow-up was 11.5 years. An index including vitamins A, C and E (ACE-Vitamin Index) was calculated. Vitamin intake was extracted from participants' dietary data and vitamin supplements, if taken. Information on glaucoma incidence was collected by previously validated self-reported questionnaires. The association between glaucoma and vitamin intake was assessed by repeated-measures Cox regression using multi-adjusted hazard ratios.

Results: A total of 251 (1.3%) cases of glaucoma were detected. Participants with a higher ACE-Vitamin Index presented a reduced risk of glaucoma compared to participants with lower consumption (adjusted HR = 0.73; 95% CI, (0.55-0.98)). When each vitamin was analyzed individually, none of them had a significant protective effect. The protective effect of the ACE-Vitamin Index was higher in men and older participants (≥55 year).

Conclusions: The consumption of vitamins A, C and E considered separately do not seem to exert a protective effect against glaucoma, but when these vitamins are considered together, they are associated with a lower risk of glaucoma.

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