The Role of Epigenetics in Neuroinflammatory-Driven Diseases

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Dec 11

PMID 36499544

Authors

Sebastiano Giallongo

Lucia Longhitano

Simona Denaro

Simona DAprile

Filippo Torrisi

Enrico La Spina

Cesarina Giallongo

Giuliana Mannino

Debora Lo Furno

Agata Zappala

Rosario Giuffrida

Rosalba Parenti

Giovanni Li Volti

Daniele Tibullo

Nunzio Vicario

Affiliations

Soon will be listed here.

Abstract

Neurodegenerative disorders are characterized by the progressive loss of central and/or peripheral nervous system neurons. Within this context, neuroinflammation comes up as one of the main factors linked to neurodegeneration progression. In fact, neuroinflammation has been recognized as an outstanding factor for Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and multiple sclerosis (MS). Interestingly, neuroinflammatory diseases are characterized by dramatic changes in the epigenetic profile, which might provide novel prognostic and therapeutic factors towards neuroinflammatory treatment. Deep changes in DNA and histone methylation, along with histone acetylation and altered non-coding RNA expression, have been reported at the onset of inflammatory diseases. The aim of this work is to review the current knowledge on this field.

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