Evidence for Multilevel Chemopreventive Activities of Natural Phenols from Functional Genomic Studies of Curcumin, Resveratrol, Genistein, Quercetin, and Luteolin

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Dec 11

PMID 36499286

Authors

Lukasz Huminiecki

Affiliations

Soon will be listed here.

Abstract

Herein, I present an updated and contextualized literature review of functional genomic studies of natural phenols in the context of cancer. I suggest multilevel chemopreventive and anticancer mechanisms of action, which are shared by multiple dietary natural phenols. Specifically, I cite evidence that curcumin and resveratrol have multilevel anti-cancer effects through: (1) inducing either p53-dependent or p53-independent apoptosis in cancer cell lines, (2) acting as potent regulators of expression of oncogenic and anti-oncogenic microRNAs, and (3) inducing complex epigenetic changes that can switch off oncogenes/switch on anti-oncogenes. There is no simple reductionist explanation for anti-cancer effects of curcumin and resveratrol. More generally, multilevel models of chemoprevention are suggested for related natural phenols and flavonoids such as genistein, quercetin, or luteolin.

Citing Articles

The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and,....

Hart D Int J Mol Sci. 2024; 25(7).

PMID: 38612676 PMC: 11011715. DOI: 10.3390/ijms25073866.

Elucidation of the Molecular Mechanism of Compound Danshen Dripping Pills against Angina Pectoris based on Network Pharmacology and Molecular Docking.

Tian X, Yin S, Liu Z, Cao J, Liu X, Qiu Q Curr Pharm Des. 2024; 30(16):1247-1264.

PMID: 38584551 DOI: 10.2174/0113816128287109240321074628.

Enhancing the bioavailability and activity of natural antioxidants with nanobubbles and nanoparticles.

colic M, Kraljevic Pavelic S, Persuric Z, Agaj A, Bulog A, Pavelic K Redox Rep. 2024; 29(1):2333619.

PMID: 38577911 PMC: 11000614. DOI: 10.1080/13510002.2024.2333619.

Natural products targeting the MAPK-signaling pathway in cancer: overview.

Shi A, Liu L, Li S, Qi B J Cancer Res Clin Oncol. 2024; 150(1):6.

PMID: 38193944 PMC: 10776710. DOI: 10.1007/s00432-023-05572-7.

Antitumor Activity of Luteolin Against Ehrlich Solid Carcinoma in Rats via Blocking Wnt/β-Catenin/SMAD4 Pathway.

Aljohani H, E Khodier A, Al-Gayyar M Cureus. 2023; 15(5):e39789.

PMID: 37265908 PMC: 10231869. DOI: 10.7759/cureus.39789.

References

Huminiecki L, Horbanczuk J, Atanasov A . The functional genomic studies of curcumin. Semin Cancer Biol. 2017; 46:107-118. DOI: 10.1016/j.semcancer.2017.04.002. View

Wang X, Gorospe M, Huang Y, Holbrook N . p27Kip1 overexpression causes apoptotic death of mammalian cells. Oncogene. 1998; 15(24):2991-7. DOI: 10.1038/sj.onc.1201450. View

Sharma R, Gescher A, Steward W . Curcumin: the story so far. Eur J Cancer. 2005; 41(13):1955-68. DOI: 10.1016/j.ejca.2005.05.009. View

Aravind L, Dixit V, Koonin E . Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. Science. 2001; 291(5507):1279-84. DOI: 10.1126/science.291.5507.1279. View

Karunagaran D, Rashmi R, Santhosh Kumar T . Induction of apoptosis by curcumin and its implications for cancer therapy. Curr Cancer Drug Targets. 2005; 5(2):117-29. DOI: 10.2174/1568009053202081. View

Guo Y, Wu R, Gaspar J, Sargsyan D, Su Z, Zhang C . DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice. Carcinogenesis. 2018; 39(5):669-680. PMC: 6248359. DOI: 10.1093/carcin/bgy043. View

Talib W, Al-Hadid S, Ali M, Al-Yasari I, Ali M . Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action. Breast Cancer (Dove Med Press). 2018; 10:207-217. PMC: 6276637. DOI: 10.2147/BCTT.S167812. View

Mirzaei H, Masoudifar A, Sahebkar A, Zare N, Nahand J, Rashidi B . MicroRNA: A novel target of curcumin in cancer therapy. J Cell Physiol. 2017; 233(4):3004-3015. DOI: 10.1002/jcp.26055. View

Robertson K . DNA methylation and human disease. Nat Rev Genet. 2005; 6(8):597-610. DOI: 10.1038/nrg1655. View

10.

Hardy T, Tollefsbol T . Epigenetic diet: impact on the epigenome and cancer. Epigenomics. 2011; 3(4):503-18. PMC: 3197720. DOI: 10.2217/epi.11.71. View

11.

Levine A . p53, the cellular gatekeeper for growth and division. Cell. 1997; 88(3):323-31. DOI: 10.1016/s0092-8674(00)81871-1. View

12.

Zhang B, Pan X, Cobb G, Anderson T . microRNAs as oncogenes and tumor suppressors. Dev Biol. 2006; 302(1):1-12. DOI: 10.1016/j.ydbio.2006.08.028. View

13.

Noratto G, Jutooru I, Safe S, Angel-Morales G, Mertens-Talcott S . The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis. Mol Nutr Food Res. 2013; 57(9):1638-48. DOI: 10.1002/mnfr.201200609. View

14.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

15.

Sirerol J, Rodriguez M, Mena S, Asensi M, Estrela J, Ortega A . Role of Natural Stilbenes in the Prevention of Cancer. Oxid Med Cell Longev. 2016; 2016:3128951. PMC: 4698548. DOI: 10.1155/2016/3128951. View

16.

Notas G, Nifli A, Kampa M, Pelekanou V, Alexaki V, Theodoropoulos P . Quercetin accumulates in nuclear structures and triggers specific gene expression in epithelial cells. J Nutr Biochem. 2011; 23(6):656-66. DOI: 10.1016/j.jnutbio.2011.03.010. View

17.

Lubecka K, Kurzava L, Flower K, Buvala H, Zhang H, Teegarden D . Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity. Carcinogenesis. 2016; 37(7):656-68. PMC: 4936385. DOI: 10.1093/carcin/bgw048. View

18.

Selvi R, Swaminathan A, Chatterjee S, Shanmugam M, Li F, Ramakrishnan G . Inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model. Oncotarget. 2015; 6(41):43806-18. PMC: 4791268. DOI: 10.18632/oncotarget.6245. View

19.

Beetch M, Lubecka K, Shen K, Flower K, Harandi-Zadeh S, Suderman M . Stilbenoid-Mediated Epigenetic Activation of Semaphorin 3A in Breast Cancer Cells Involves Changes in Dynamic Interactions of DNA with DNMT3A and NF1C Transcription Factor. Mol Nutr Food Res. 2019; 63(19):e1801386. DOI: 10.1002/mnfr.201801386. View

20.

Deveraux Q, Reed J . IAP family proteins--suppressors of apoptosis. Genes Dev. 1999; 13(3):239-52. DOI: 10.1101/gad.13.3.239. View