TULA-Family Regulators of Platelet Activation

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Dec 11

PMID 36499237

Authors

Satya P Kunapuli

Alexander Y Tsygankov

Affiliations

Soon will be listed here.

Abstract

The two members of the UBASH3/TULA/STS-protein family have been shown to critically regulate cellular processes in multiple biological systems. The regulatory function of TULA-2 (also known as UBASH3B or STS-1) in platelets is one of the best examples of the involvement of UBASH3/TULA/STS proteins in cellular regulation. TULA-2 negatively regulates platelet signaling mediated by ITAM- and hemITAM-containing membrane receptors that are dependent on the protein tyrosine kinase Syk, which currently represents the best-known dephosphorylation target of TULA-2. The biological responses of platelets to collagen and other physiological agonists are significantly downregulated as a result. The protein structure, enzymatic activity and regulatory functions of UBASH3/TULA/STS proteins in the context of platelet responses and their regulation are discussed in this review.

Citing Articles

The Ubiquitin-Associated and SH3 Domain-Containing Proteins (UBASH3) Family in Mammalian Development and Immune Response.

Vukojevic K, Soljic V, Martinovic V, Raguz F, Filipovic N Int J Mol Sci. 2024; 25(3).

PMID: 38339213 PMC: 10855836. DOI: 10.3390/ijms25031932.

TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the Family.

Tsygankov A Int J Mol Sci. 2023; 24(11).

PMID: 37298079 PMC: 10253181. DOI: 10.3390/ijms24119126.

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