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Multiple Chemical Sensitivity Syndrome: First Symptoms and Evolution of the Clinical Picture: Case-Control Study/Epidemiological Case-Control Study

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Publisher MDPI
Date 2022 Dec 11
PMID 36497963
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Abstract

Multiple chemical sensitivity (MCS) is a chronic condition characterized by the appearance of symptoms caused by exposure to chemical compounds that are tolerable for the general population. It mainly affects middle-aged women. There are very few studies focusing on the most frequent symptoms of MCS considering age groups and gender. The main goal of this study was to find the most frequent symptoms both at the onset of the disease and at the present time describing them by age groups. The QEESI (Quick Environmental Exposure and Sensitivity Inventory) questionnaire, Scale 3 which assesses symptoms and their severity, was used as a diagnostic tool for the disease. A case-control study was conducted with the participation of 210 people. Of the cases, 94.3% were women. The symptoms that most often manifested first were airway and mucous membrane alterations (68.9%). In the development of the disease, we found cognitive alterations (OR = 31.25), heart or chest problems (OR = 22.49), neuromuscular problems (OR = 20.00) and head-related symptomatology (OR = 19.29). Identifying the most frequent pattern of symptoms by age group and sex will allow an early diagnosis of the disease to improve its prognosis and treatment.

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References
1.
Hojo S, Mizukoshi A, Azuma K, Okumura J, Ishikawa S, Miyata M . Survey on changes in subjective symptoms, onset/trigger factors, allergic diseases, and chemical exposures in the past decade of Japanese patients with multiple chemical sensitivity. Int J Hyg Environ Health. 2018; 221(8):1085-1096. DOI: 10.1016/j.ijheh.2018.08.001. View

2.
Cui X, Lu X, Hiura M, Oda M, Miyazaki W, Katoh T . Evaluation of genetic polymorphisms in patients with multiple chemical sensitivity. PLoS One. 2013; 8(8):e73708. PMC: 3742528. DOI: 10.1371/journal.pone.0073708. View

3.
Johansson A, Bramerson A, Millqvist E, Nordin S, Bende M . Prevalence and risk factors for self-reported odour intolerance: the Skövde population-based study. Int Arch Occup Environ Health. 2005; 78(7):559-64. DOI: 10.1007/s00420-005-0616-8. View

4.
Baldwin C, Bell I . Increased cardiopulmonary disease risk in a community-based sample with chemical odor intolerance: implications for women's health and health-care utilization. Arch Environ Health. 1998; 53(5):347-53. DOI: 10.1080/00039899809605720. View

5.
Meggs W, Dunn K, Bloch R, Goodman P, Davidoff A . Prevalence and nature of allergy and chemical sensitivity in a general population. Arch Environ Health. 1996; 51(4):275-82. DOI: 10.1080/00039896.1996.9936026. View