Stimulation of the Vascular Endothelium and Angiogenesis by Blood-Flow-Restricted Exercise

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Dec 11

PMID 36497934

Authors

Mikolaj Maga

Martyna Schonborn

Agnieszka Wachsmann-Maga

Agnieszka Sliwka

Jakub Krezel

Aleksandra Wlodarczyk

Marta Olszewska

Roman Nowobilski

Affiliations

Soon will be listed here.

Abstract

Blood-flow-restricted exercise (BFRE) has been gaining constantly increasing interest in rehabilitation, but its influence on endothelial functions has not been well studied yet. Our aim is to examine the influence of low-resistance BFRE on endothelial functions and angiogenesis. This prospective cross-over study involved 35 young healthy adults. They conducted a 21-min low-resistant exercise with blood flow restricted by pressure cuffs placed on arms and tights. They also did the same training but without blood flow restriction. Endothelial parameters and angiogenesis biomarkers were evaluated before and up to 20 min after exercise. Both types of exercise increased Flow-Mediated Dilatation (FMD) but elevation after BFRE was more significant compared to the controls. The stiffness index decreased only after BFRE, while the reflection index decreased significantly after both types of exercise but was higher after BFRE. Platelet endothelial cell adhesion molecule (PECAM-1) and vascular endothelial growth factor receptor 2 (VEGFR-2) concentrations were increased by both exercise types but elevations were higher after BFRE compared to the controls. Only BFRE elevated the mean serum CD34 protein concentration. Based on these results, we can assume that low-resistance BFR exercise stimulates angiogenesis and improves endothelial functions more significantly compared to the same training performed without blood flow restriction.

Citing Articles

Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis-A Systematic Review with Meta-Analysis.

Maga M, Wachsmann-Maga A, Batko K, Wlodarczyk A, Klapacz P, Krezel J Biomedicines. 2023; 11(6).

PMID: 37371696 PMC: 10295844. DOI: 10.3390/biomedicines11061601.

The Effect of Low Intensity Resistance Training with Blood Flow Restriction on Fall Resistance in Middle-Aged and Older Adults: A Meta-Analysis.

Li S, Wang P, Xin X, Zhou X, Wang J, Zhao J Int J Environ Res Public Health. 2023; 20(6).

PMID: 36981632 PMC: 10049074. DOI: 10.3390/ijerph20064723.

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