Tumour Colonisation of Is Associated with Decreased Survival in Colorectal Cancer Patients

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 Dec 11

PMID 36497419

Authors

Thyra Lowenmark

Anna Lofgren-Burstrom

Carl Zingmark

Ingrid Ljuslinder

Michael Dahlberg

Sofia Edin

Richard Palmqvist

Affiliations

Soon will be listed here.

Abstract

Increasing evidence suggests that the gut microbiota may impact colorectal cancer (CRC) development and progression. In this study, the tumour colonisation of two CRC-associated bacteria, and , was studied in relation to patient survival in a cohort of 257 CRC patients. Colonisation of and was analysed in fresh frozen tumour tissue (n = 112) and in faeces (n = 250) by qPCR. When analysing tumour tissues, both and were found to be associated with decreased five-year cancer-specific survival, an association that remained significant in multivariable analysis for . Furthermore, we found significant associations of high levels of and with tumour molecular characteristics, i.e., tumours mutated in , and tumours of the MSI subtype. The analysis of faecal samples showed weaker associations with prognosis and tumour molecular characteristics. In conclusion, our findings support a novel association of tumour colonisation of with decreased patient survival. A better understanding of the role of the gut microbiota in CRC might contribute to the advancement of prognostic tools and new targets for therapy.

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References

Lowenmark T, Lofgren-Burstrom A, Zingmark C, Eklof V, Dahlberg M, Nyunt Wai S . Parvimonas micra as a putative non-invasive faecal biomarker for colorectal cancer. Sci Rep. 2020; 10(1):15250. PMC: 7499209. DOI: 10.1038/s41598-020-72132-1. View

Drewes J, White J, Dejea C, Fathi P, Iyadorai T, Vadivelu J . High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia. NPJ Biofilms Microbiomes. 2017; 3:34. PMC: 5707393. DOI: 10.1038/s41522-017-0040-3. View

Glimelius B, Melin B, Enblad G, Alafuzoff I, Beskow A, Ahlstrom H . U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden. Acta Oncol. 2017; 57(2):187-194. DOI: 10.1080/0284186X.2017.1337926. View

Lowenmark T, Li X, Lofgren-Burstrom A, Zingmark C, Ling A, Kellgren T . Parvimonas micra is associated with tumour immune profiles in molecular subtypes of colorectal cancer. Cancer Immunol Immunother. 2022; 71(10):2565-2575. PMC: 9463256. DOI: 10.1007/s00262-022-03179-4. View

Bullman S, Pedamallu C, Sicinska E, Clancy T, Zhang X, Cai D . Analysis of persistence and antibiotic response in colorectal cancer. Science. 2017; 358(6369):1443-1448. PMC: 5823247. DOI: 10.1126/science.aal5240. View

Chen Y, Chen Y, Zhang J, Cao P, Su W, Deng Y . Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression. Theranostics. 2020; 10(1):323-339. PMC: 6929621. DOI: 10.7150/thno.38870. View

Wong S, Yu J . Gut microbiota in colorectal cancer: mechanisms of action and clinical applications. Nat Rev Gastroenterol Hepatol. 2019; 16(11):690-704. DOI: 10.1038/s41575-019-0209-8. View

Kim Y, Cho N, Kang G . Prognostic and clinicopathological significance of Fusobacterium nucleatum in colorectal cancer: a systemic review and meta-analysis. J Pathol Transl Med. 2022; 56(3):144-151. PMC: 9119808. DOI: 10.4132/jptm.2022.03.13. View

Boland C, Goel A . Microsatellite instability in colorectal cancer. Gastroenterology. 2010; 138(6):2073-2087.e3. PMC: 3037515. DOI: 10.1053/j.gastro.2009.12.064. View

10.

Tjalsma H, Boleij A, Marchesi J, Dutilh B . A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nat Rev Microbiol. 2012; 10(8):575-82. DOI: 10.1038/nrmicro2819. View

11.

Chen J, Pitmon E, Wang K . Microbiome, inflammation and colorectal cancer. Semin Immunol. 2017; 32:43-53. DOI: 10.1016/j.smim.2017.09.006. View

12.

Chen Y, Lu Y, Ke Y, Li Y . Prognostic impact of the Fusobacterium nucleatum status in colorectal cancers. Medicine (Baltimore). 2019; 98(39):e17221. PMC: 6775385. DOI: 10.1097/MD.0000000000017221. View

13.

Purcell R, Visnovska M, Biggs P, Schmeier S, Frizelle F . Distinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer. Sci Rep. 2017; 7(1):11590. PMC: 5599497. DOI: 10.1038/s41598-017-11237-6. View

14.

Chen S, Su T, Zhang Y, Lee A, He J, Ge Q . promotes colorectal cancer metastasis by modulating /KRT7. Gut Microbes. 2020; 11(3):511-525. PMC: 7524269. DOI: 10.1080/19490976.2019.1695494. View

15.

Rubinstein M, Baik J, Lagana S, Han R, Raab W, Sahoo D . promotes colorectal cancer by inducing Wnt/β-catenin modulator Annexin A1. EMBO Rep. 2019; 20(4). PMC: 6446206. DOI: 10.15252/embr.201847638. View

16.

de Carvalho A, Pereira L, Datorre J, Dos Santos W, Berardinelli G, Matsushita M . Microbiota Profile and Impact of in Colorectal Cancer Patients of Barretos Cancer Hospital. Front Oncol. 2019; 9:813. PMC: 6727361. DOI: 10.3389/fonc.2019.00813. View

17.

Xu J, Yang M, Wang D, Zhang S, Yan S, Zhu Y . Alteration of the abundance of in the gut along the adenoma-carcinoma sequence. Oncol Lett. 2020; 20(4):106. PMC: 7439112. DOI: 10.3892/ol.2020.11967. View

18.

Morgan E, Arnold M, Gini A, Lorenzoni V, Cabasag C, Laversanne M . Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut. 2023; 72(2):338-344. DOI: 10.1136/gutjnl-2022-327736. View

19.

Wirbel J, Pyl P, Kartal E, Zych K, Kashani A, Milanese A . Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. Nat Med. 2019; 25(4):679-689. PMC: 7984229. DOI: 10.1038/s41591-019-0406-6. View

20.

Wei Z, Cao S, Liu S, Yao Z, Sun T, Li Y . Could gut microbiota serve as prognostic biomarker associated with colorectal cancer patients' survival? A pilot study on relevant mechanism. Oncotarget. 2016; 7(29):46158-46172. PMC: 5216788. DOI: 10.18632/oncotarget.10064. View