Men with Oligozoospermia Had Lower Level of Seminal Plasma Pyridoxine Compared to Normozoospermic Men

Overview

Journal Heliyon

Specialty Social Sciences

Date 2022 Dec 9

PMID 36483303

Authors

Saleem A Banihani

Shefa M Aljabali

Affiliations

Soon will be listed here.

Abstract

The contribution of pyridoxine on various human disorders has been revealed in so many studies; however, this contribution on poor semen quality has yet to be investigated. Here, we intended to measure the level of seminal plasma pyridoxine (SPP) in men with oligozoospermia compared to normozoospermic men. Thirty-three men with oligozoospermia and forty-three normozoospermic men were randomly enrolled in this study. Collected semen were tested for sperm motility, sperm concentration, semen volume, and pyridoxine status. Liquid chromatography with tandem mass spectrometry was used to measure SPP in the collected samples. There was a significant reduction ( < 0.0001) in the concentrations of SPP in men with oligozoospermia (0.79 ± 0.41 μg L) compared to normozoospermic men (3.17 ± 0.96 μg L). Besides, SPP was not significantly correlated ( > 0.05) with sperm motility, sperm concentration, and semen volume in both tested groups, but, independently, it was found to be positively correlated ( = 0.0154) with male age in oligozoospermic group. Men with oligozoospermia had lower level of SPP compared to normozoospermic men. These results may open a new research gate for the use of pyridoxine in the management of male infertility.

Citing Articles

Role of pyridoxine and oxidative stress in asthenozoospermia.

Bdeir R, Aljabali S, Banihani S Heliyon. 2024; 10(14):e34799.

PMID: 39148988 PMC: 11325350. DOI: 10.1016/j.heliyon.2024.e34799.

Male Infertility: Causes and Management at a Tertiary Care Center in India.

Choudhary S, Mishra V, Kumari P, Sheth H, Ahmad R, Haque M Cureus. 2023; 15(9):e45584.

PMID: 37736241 PMC: 10509730. DOI: 10.7759/cureus.45584.

Morphological and Molecular Bases of Male Infertility: A Closer Look at Sperm Flagellum.

Pereira R, Sousa M Genes (Basel). 2023; 14(2).

PMID: 36833310 PMC: 9956255. DOI: 10.3390/genes14020383.

References

Boxmeer J, Smit M, Weber R, Lindemans J, Romijn J, Eijkemans M . Seminal plasma cobalamin significantly correlates with sperm concentration in men undergoing IVF or ICSI procedures. J Androl. 2007; 28(4):521-7. DOI: 10.2164/jandrol.106.001982. View

Fiser B, Jojart B, Csizmadia I, Viskolcz B . Glutathione--hydroxyl radical interaction: a theoretical study on radical recognition process. PLoS One. 2013; 8(9):e73652. PMC: 3767814. DOI: 10.1371/journal.pone.0073652. View

Dutta S, Majzoub A, Agarwal A . Oxidative stress and sperm function: A systematic review on evaluation and management. Arab J Urol. 2019; 17(2):87-97. PMC: 6600059. DOI: 10.1080/2090598X.2019.1599624. View

Zhou S, Chen X, Ni X, Liu Y, Zhang H, Dong M . Pyridoxal-5'-phosphate-dependent enzyme GenB3 Catalyzes C-3',4'-dideoxygenation in gentamicin biosynthesis. Microb Cell Fact. 2021; 20(1):65. PMC: 7941887. DOI: 10.1186/s12934-021-01558-7. View

Dong H, Pi F, Ding Z, Chen W, Pang S, Dong W . Efficacy of Supplementation with B Vitamins for Stroke Prevention: A Network Meta-Analysis of Randomized Controlled Trials. PLoS One. 2015; 10(9):e0137533. PMC: 4565665. DOI: 10.1371/journal.pone.0137533. View

Shahat A, Rizzoto G, Kastelic J . Amelioration of heat stress-induced damage to testes and sperm quality. Theriogenology. 2020; 158:84-96. DOI: 10.1016/j.theriogenology.2020.08.034. View

Banihani S, Aljabali S . Seminal plasma vitamin B levels in men with asthenozoospermia and men with normal sperm motility, a measurement using liquid chromatography with tandem mass spectrometry. Andrologia. 2020; 52(4):e13556. DOI: 10.1111/and.13556. View

Mhaidat N, Alzoubi K, Khabour O, Tashtoush N, Banihani S, Abdul-Razzak K . Exploring the effect of vitamin C on sleep deprivation induced memory impairment. Brain Res Bull. 2015; 113:41-7. DOI: 10.1016/j.brainresbull.2015.02.002. View

Natera J, Massad W, Garcia N . The role of vitamin B6 as an antioxidant in the presence of vitamin B2-photogenerated reactive oxygen species. A kinetic and mechanistic study. Photochem Photobiol Sci. 2012; 11(6):938-45. DOI: 10.1039/c2pp05318g. View

10.

Banihani S . Ginger and Testosterone. Biomolecules. 2018; 8(4). PMC: 6316093. DOI: 10.3390/biom8040119. View

11.

Belhan S, Comakli S, Kucukler S, Gulyuz F, Yildirim S, Yener Z . Effect of chrysin on methotrexate-induced testicular damage in rats. Andrologia. 2018; 51(1):e13145. DOI: 10.1111/and.13145. View

12.

Boxmeer J, Smit M, Utomo E, Romijn J, Eijkemans M, Lindemans J . Low folate in seminal plasma is associated with increased sperm DNA damage. Fertil Steril. 2008; 92(2):548-56. DOI: 10.1016/j.fertnstert.2008.06.010. View

13.

Yang J, Minkler P, Grove D, Wang R, Willard B, Dweik R . Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B. Commun Biol. 2019; 2:194. PMC: 6529520. DOI: 10.1038/s42003-019-0431-5. View

14.

Puts J, de Groot M, Haex M, Jakobs B . Simultaneous Determination of Underivatized Vitamin B1 and B6 in Whole Blood by Reversed Phase Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry. PLoS One. 2015; 10(7):e0132018. PMC: 4489891. DOI: 10.1371/journal.pone.0132018. View

15.

Arcaniolo D, Favilla V, Tiscione D, Pisano F, Bozzini G, Creta M . Is there a place for nutritional supplements in the treatment of idiopathic male infertility?. Arch Ital Urol Androl. 2014; 86(3):164-70. DOI: 10.4081/aiua.2014.3.164. View

16.

Vujkovic M, de Vries J, Dohle G, Bonsel G, Lindemans J, Macklon N . Associations between dietary patterns and semen quality in men undergoing IVF/ICSI treatment. Hum Reprod. 2009; 24(6):1304-12. DOI: 10.1093/humrep/dep024. View

17.

Calderon-Ospina C, Nava-Mesa M . B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci Ther. 2019; 26(1):5-13. PMC: 6930825. DOI: 10.1111/cns.13207. View

18.

Jeon J, Park K . Dietary Vitamin B Intake Associated with a Decreased Risk of Cardiovascular Disease: A Prospective Cohort Study. Nutrients. 2019; 11(7). PMC: 6682858. DOI: 10.3390/nu11071484. View

19.

Banihani S . A Systematic Review Evaluating the Effect of Vitamin B6 on Semen Quality. Urol J. 2018; 15(1):1-5. DOI: 10.22037/uj.v0i0.3808. View

20.

Dubick M, Gretz D, Majumdar A . Overt vitamin B-6 deficiency affects rat pancreatic digestive enzyme and glutathione reductase activities. J Nutr. 1995; 125(1):20-5. DOI: 10.1093/jn/125.1.20. View