The Physiological Mechanism and Effect of Resistance Exercise on Cognitive Function in the Elderly People

Overview

Journal Front Public Health

Specialty Public Health

Date 2022 Dec 9

PMID 36483263

Authors

Aijie Cheng

Zhiwei Zhao

Hengxu Liu

Jinxin Yang

Jiong Luo

Affiliations

Soon will be listed here.

Abstract

Background: As brain function declines and cognitive ability declines, the benefits of resistance exercise to the brain of older people are gradually gaining attention.

Objective: The purpose of this review is to explore the mechanism and relationship between physiological factors such as vascular and neuronal degeneration and cognitive decline, and to categorize the differences in the effects of an acute and chronic resistance exercise intervention on cognitive function in healthy elderly people and the possible regulators of cognitive effects.

Methods: Using PubMed, Elsevier, Web of Science, X-MOL, CNKI, and Taiwan academic literature database, the research papers published in relevant journals at home and abroad until April 2022 were searched with Chinese and English keywords such as Resistance exercise, the elderly, hippocampus, memory performance, neurons, cognitive function. Pedro scale was used to check the quality of various documents, and the relevant research documents were obtained with the resistance exercise elements as the main axis for comprehensive analysis.

Results And Conclusion: (1) Resistance exercise can have a beneficial effect on the brain function of the elderly through blood flow changes, stimulate nerve conduction substances and endocrine metabolism, promote cerebrovascular regeneration and gray matter volume of the brain, and prevent or delay the cognitive function degradation such as memory and attention of the elderly; (2) Acute resistance can temporarily stimulate hormone secretion and significantly improve the effect of short-term memory test, but it has little effect on the cognitive performance of the elderly; (3) Moderate-high intensity resistance exercise (50-80%1RM, 1-3 times/week, 2-3 groups/time) lasting for at least 6 months is more prominent for the improvement of cognitive function of the elderly, while the parameters such as resistance exercise intensity, exercise amount, duration, evaluation test time and differences of subjects may have different degrees of influence on cognitive benefits.

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References

Coelho F, Pereira D, Lustosa L, Silva J, Dias J, Dias R . Physical therapy intervention (PTI) increases plasma brain-derived neurotrophic factor (BDNF) levels in non-frail and pre-frail elderly women. Arch Gerontol Geriatr. 2011; 54(3):415-20. DOI: 10.1016/j.archger.2011.05.014. View

Loriette C, Ziane C, Ben Hamed S . Neurofeedback for cognitive enhancement and intervention and brain plasticity. Rev Neurol (Paris). 2021; 177(9):1133-1144. DOI: 10.1016/j.neurol.2021.08.004. View

Chang Y, Labban J, Gapin J, Etnier J . The effects of acute exercise on cognitive performance: a meta-analysis. Brain Res. 2012; 1453:87-101. DOI: 10.1016/j.brainres.2012.02.068. View

Bakker E, Bacskai B, Arbel-Ornath M, Aldea R, Bedussi B, Morris A . Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases. Cell Mol Neurobiol. 2016; 36(2):181-94. PMC: 4844641. DOI: 10.1007/s10571-015-0273-8. View

Jacobs B, van Praag H, Gage F . Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry. 2000; 5(3):262-9. DOI: 10.1038/sj.mp.4000712. View

Tanaka M, Saito S, Inoue T, Satoh-Asahara N, Ihara M . Potential Therapeutic Approaches for Cerebral Amyloid Angiopathy and Alzheimer's Disease. Int J Mol Sci. 2020; 21(6). PMC: 7139812. DOI: 10.3390/ijms21061992. View

Kim S, Ahn J, Yang H, Lee P, Koh G, Jeong Y . Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer's disease mouse model. Acta Neuropathol Commun. 2020; 8(1):181. PMC: 7643327. DOI: 10.1186/s40478-020-01042-0. View

Vitiello M, Moe K, Merriam G, Mazzoni G, Buchner D, Schwartz R . Growth hormone releasing hormone improves the cognition of healthy older adults. Neurobiol Aging. 2006; 27(2):318-23. DOI: 10.1016/j.neurobiolaging.2005.01.010. View

Floel A, Ruscheweyh R, Kruger K, Willemer C, Winter B, Volker K . Physical activity and memory functions: are neurotrophins and cerebral gray matter volume the missing link?. Neuroimage. 2009; 49(3):2756-63. DOI: 10.1016/j.neuroimage.2009.10.043. View

10.

Soshi T, Andersson M, Kawagoe T, Nishiguchi S, Yamada M, Otsuka Y . Prefrontal Plasticity after a 3-Month Exercise Intervention in Older Adults Relates to Enhanced Cognitive Performance. Cereb Cortex. 2021; 31(10):4501-4517. DOI: 10.1093/cercor/bhab102. View

11.

Takano H, Morita T, Iida H, Asada K, Kato M, Uno K . Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow. Eur J Appl Physiol. 2005; 95(1):65-73. DOI: 10.1007/s00421-005-1389-1. View

12.

Bentzon J . Targeting Inflammation in Atherosclerosis. J Am Coll Cardiol. 2016; 68(25):2794-2796. DOI: 10.1016/j.jacc.2016.11.005. View

13.

Tsai C, Ukropec J, Ukropcova B, Pai M . An acute bout of aerobic or strength exercise specifically modifies circulating exerkine levels and neurocognitive functions in elderly individuals with mild cognitive impairment. Neuroimage Clin. 2018; 17:272-284. PMC: 5842646. DOI: 10.1016/j.nicl.2017.10.028. View

14.

Lucas S, Ainslie P, Murrell C, Thomas K, Franz E, Cotter J . Effect of age on exercise-induced alterations in cognitive executive function: relationship to cerebral perfusion. Exp Gerontol. 2012; 47(8):541-51. DOI: 10.1016/j.exger.2011.12.002. View

15.

Fragala M, Beyer K, Jajtner A, Townsend J, Pruna G, Boone C . Resistance exercise may improve spatial awareness and visual reaction in older adults. J Strength Cond Res. 2014; 28(8):2079-87. DOI: 10.1519/JSC.0000000000000520. View

16.

Schmidt W, Endres M, Dimeo F, Jungehulsing G . Train the vessel, gain the brain: physical activity and vessel function and the impact on stroke prevention and outcome in cerebrovascular disease. Cerebrovasc Dis. 2013; 35(4):303-12. DOI: 10.1159/000347061. View

17.

Jhaveri D, Tedoldi A, Hunt S, Sullivan R, Watts N, Power J . Evidence for newly generated interneurons in the basolateral amygdala of adult mice. Mol Psychiatry. 2017; 23(3):521-532. PMC: 5822453. DOI: 10.1038/mp.2017.134. View

18.

Basso J, Suzuki W . The Effects of Acute Exercise on Mood, Cognition, Neurophysiology, and Neurochemical Pathways: A Review. Brain Plast. 2018; 2(2):127-152. PMC: 5928534. DOI: 10.3233/BPL-160040. View

19.

Tsai C, Pai M, Ukropec J, Ukropcova B . Distinctive Effects of Aerobic and Resistance Exercise Modes on Neurocognitive and Biochemical Changes in Individuals with Mild Cognitive Impairment. Curr Alzheimer Res. 2019; 16(4):316-332. DOI: 10.2174/1567205016666190228125429. View

20.

Islam O, Loo T, Heese K . Brain-derived neurotrophic factor (BDNF) has proliferative effects on neural stem cells through the truncated TRK-B receptor, MAP kinase, AKT, and STAT-3 signaling pathways. Curr Neurovasc Res. 2009; 6(1):42-53. DOI: 10.2174/156720209787466028. View