Monkeypox: An Emerging Zoonotic Pathogen

Overview

Journal World J Virol

Publisher Baishideng Publishing Group

Date 2022 Dec 9

PMID 36483104

Authors

Masoumeh Beig

Mehrdad Mohammadi

Fatemeh Nafe Monfared

Somaieh Nasereslami

Affiliations

Soon will be listed here.

Abstract

Monkeypox virus (MPXV), which belongs to the orthopoxvirus genus, causes zoonotic viral disease. This review discusses the biology, epidemiology, and evolution of MPXV infection, particularly cellular, human, and viral factors, virus transmission dynamics, infection, and persistence in nature. This review also describes the role of recombination, gene loss, and gene gain in MPXV evol-vement and the role of signal transduction in MPXV infection and provides an overview of the current access to therapeutic options for the treatment and prevention of MPXV. Finally, this review highlighted gaps in knowledge and proposed future research endeavors to address the unresolved questions.

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