Fabrication of Gentamicin Loaded Col-I/HA Multilayers Modified Titanium Coatings for Prevention of Implant Infection

Overview

Journal Front Chem

Specialty Chemistry

Date 2022 Dec 9

PMID 36482941

Authors

Le Ma

Jiajia Zong

Xiaowei Xun

Xiaoming Hu

Zejing Chen

Quanchao Zhang

Mengxia Peng

Botao Song

Haiyong Ao

Affiliations

Soon will be listed here.

Abstract

In this study, gentamicin loaded collagen I/hyaluronic acid multilayers modified titanium coating (TC-AA(C/H)-G) was fabricated a layer-by-layer (LBL) covalent immobilization method. The drug releasing properties of collagen I/Hyaluronic acid (Col-I/HA) multilayers and the effect of loaded gentamicin on the antibacterial properties and cytocompatibility of modified TC were investigated. The gentamicin release assay indicated that the Col-I/HA multilayers modified TC exhibited agreeable drug-loading amount (537.22 ± 29.66 µg of gentamicin) and controlled-release performance (240 h of sustained release time). TC-AA(C/H)-G revealed satisfactory antibacterial activity and inhibited the colonization and biofilm formation of . Fortunately, the functions of hMSCs on TC-AA(C/H)-G did not affected by the loaded gentamicin, and TC-AA(C/H)-G could improve the adhesion, proliferation and osteogenic differentiation of cells, as well as TC-AA(C/H). animal study indicated that TC-AA(C/H)-G could effectively control intramedullary cavity infection caused by and prevent bone destruction.

Citing Articles

Cationized Decalcified Bone Matrix for Infected Bone Defect Treatment.

Chen L, Ai Y, Wu R, Guo Z, Li Y, Li J BME Front. 2024; 5:0066.

PMID: 39360181 PMC: 11445788. DOI: 10.34133/bmef.0066.

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