A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory Processing

Overview

Journal Biol Psychiatry

Publisher Elsevier

Specialty Psychiatry

Date 2022 Dec 6

PMID 36473754

Authors

Heather N Allen

Sarah Chaudhry

Veronica M Hong

Lakeisha A Lewter

Ghanshyam P Sinha

Yarimar Carrasquillo

Bradley K Taylor

Benedict J Kolber

Affiliations

Soon will be listed here.

Abstract

Background: The central amygdala (CeA) is a bilateral hub of pain and emotional processing with well-established functional lateralization. We reported that optogenetic manipulation of neural activity in the left and right CeA has opposing effects on bladder pain.

Methods: To determine the influence of calcitonin gene-related peptide (CGRP) signaling from the parabrachial nucleus on this diametrically opposed lateralization, we administered CGRP and evaluated the activity of CeA neurons in acute brain slices as well as the behavioral signs of bladder pain in the mouse.

Results: We found that CGRP increased firing in both the right and left CeA neurons. Furthermore, we found that CGRP administration in the right CeA increased behavioral signs of bladder pain and decreased bladder pain-like behavior when administered in the left CeA.

Conclusions: These studies reveal a parabrachial-to-amygdala circuit driven by opposing actions of CGRP that determines hemispheric lateralization of visceral pain.

Citing Articles

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