Interaction Between Sarcopenia and Nonalcoholic Fatty Liver Disease

Overview

Journal Clin Mol Hepatol

Specialty Gastroenterology

Date 2022 Dec 6

PMID 36472051

Authors

Sae Kyung Joo

Won Kim

Affiliations

Soon will be listed here.

Abstract

Sarcopenia and nonalcoholic fatty liver disease (NAFLD) are common health problems related to aging. Despite the differences in their diagnostic methods, several cross-sectional and longitudinal studies have revealed the close link between sarcopenia and NAFLD. Sarcopenia and NAFLD are linked by several shared pathogenetic mechanisms, including insulin resistance, hormonal imbalance, systemic inflammation, myostatin and adiponectin dysregulation, nutritional deficiencies, and physical inactivity, thus implicating a bidirectional relationship between sarcopenia and NAFLD. However, there is not sufficient data to support a direct causal relationship between sarcopenia and NAFLD. Moreover, it is currently difficult to conclude whether sarcopenia is a risk factor for nonalcoholic steatohepatitis (NASH) or is a consequence of NASH. Therefore, this review intends to touch on the shared common mechanisms and the bidirectional relationship between sarcopenia and NAFLD.

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References

Hong H, Hwang S, Choi H, Yoo H, Seo J, Kim S . Relationship between sarcopenia and nonalcoholic fatty liver disease: the Korean Sarcopenic Obesity Study. Hepatology. 2013; 59(5):1772-8. DOI: 10.1002/hep.26716. View

Koo B, Um S, Seo D, Joo S, Bae J, Park J . Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease. Liver Int. 2017; 38(4):695-705. DOI: 10.1111/liv.13587. View

Ceglia L . Vitamin D and skeletal muscle tissue and function. Mol Aspects Med. 2008; 29(6):407-14. DOI: 10.1016/j.mam.2008.07.002. View

Lee Y, Jung K, Kim S, Yoon H, Yun Y, Lee B . Sarcopaenia is associated with NAFLD independently of obesity and insulin resistance: Nationwide surveys (KNHANES 2008-2011). J Hepatol. 2015; 63(2):486-93. DOI: 10.1016/j.jhep.2015.02.051. View

Ebadi M, Montano-Loza A . Clinical relevance of skeletal muscle abnormalities in patients with cirrhosis. Dig Liver Dis. 2019; 51(11):1493-1499. DOI: 10.1016/j.dld.2019.05.034. View

McPherron A, Lawler A, Lee S . Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997; 387(6628):83-90. DOI: 10.1038/387083a0. View

Steffl M, Bohannon R, Sontakova L, Tufano J, Shiells K, Holmerova I . Relationship between sarcopenia and physical activity in older people: a systematic review and meta-analysis. Clin Interv Aging. 2017; 12:835-845. PMC: 5441519. DOI: 10.2147/CIA.S132940. View

Guillet C, Boirie Y . Insulin resistance: a contributing factor to age-related muscle mass loss?. Diabetes Metab. 2006; 31 Spec No 2:5S20-5S26. DOI: 10.1016/s1262-3636(05)73648-x. View

Zhang C, McFarlane C, Lokireddy S, Bonala S, Ge X, Masuda S . Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway. Diabetologia. 2011; 54(6):1491-501. DOI: 10.1007/s00125-011-2079-7. View

10.

Srikanthan P, Hevener A, Karlamangla A . Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III. PLoS One. 2012; 5(5):e10805. PMC: 3279294. DOI: 10.1371/journal.pone.0010805. View

11.

Zhai Y, Xiao Q, Miao J . The Relationship between NAFLD and Sarcopenia in Elderly Patients. Can J Gastroenterol Hepatol. 2018; 2018:5016091. PMC: 5892294. DOI: 10.1155/2018/5016091. View

12.

Kitajima Y, Hyogo H, Sumida Y, Eguchi Y, Ono N, Kuwashiro T . Severity of non-alcoholic steatohepatitis is associated with substitution of adipose tissue in skeletal muscle. J Gastroenterol Hepatol. 2013; 28(9):1507-14. DOI: 10.1111/jgh.12227. View

13.

Sinn D, Kang D, Kang M, Guallar E, Hong Y, Lee K . Nonalcoholic fatty liver disease and accelerated loss of skeletal muscle mass: A longitudinal cohort study. Hepatology. 2022; 76(6):1746-1754. DOI: 10.1002/hep.32578. View

14.

Zhang H, Lin S, Gao T, Zhong F, Cai J, Sun Y . Association between Sarcopenia and Metabolic Syndrome in Middle-Aged and Older Non-Obese Adults: A Systematic Review and Meta-Analysis. Nutrients. 2018; 10(3). PMC: 5872782. DOI: 10.3390/nu10030364. View

15.

Girgis C, Clifton-Bligh R, Hamrick M, Holick M, Gunton J . The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr Rev. 2012; 34(1):33-83. DOI: 10.1210/er.2012-1012. View

16.

Zhang H, Zhang X, Ma Z, Pan L, Chen Z, Han H . Irisin is inversely associated with intrahepatic triglyceride contents in obese adults. J Hepatol. 2013; 59(3):557-62. DOI: 10.1016/j.jhep.2013.04.030. View

17.

Hsieh Y, Joo S, Koo B, Lin H, Kim W . Muscle alterations are independently associated with significant fibrosis in patients with nonalcoholic fatty liver disease. Liver Int. 2020; 41(3):494-504. DOI: 10.1111/liv.14719. View

18.

Ryall J, Schertzer J, Lynch G . Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness. Biogerontology. 2008; 9(4):213-28. DOI: 10.1007/s10522-008-9131-0. View

19.

Hartwig S, Raschke S, Knebel B, Scheler M, Irmler M, Passlack W . Secretome profiling of primary human skeletal muscle cells. Biochim Biophys Acta. 2013; 1844(5):1011-7. DOI: 10.1016/j.bbapap.2013.08.004. View

20.

Wong E, Backholer K, Gearon E, Harding J, Freak-Poli R, Stevenson C . Diabetes and risk of physical disability in adults: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2014; 1(2):106-14. DOI: 10.1016/S2213-8587(13)70046-9. View