Preparation and Application of Calcium Phosphate Nanocarriers in Drug Delivery

Overview

Journal Mater Today Bio

Specialty Biomedical Engineering

Date 2022 Dec 5

PMID 36466957

Authors

Chong Qiu

Yanyan Wu

Qiuyan Guo

Qiaoli Shi

Junzhe Zhang

Yuqing Meng

Fei Xia

Jigang Wang

Affiliations

Soon will be listed here.

Abstract

Calcium phosphate nanoparticles represent promising materials for drug delivery because of its favorable properties, including biocompatibility, biodegradability and strong affinity for binding to nucleic acids (pDNA, siRNA, miRNA, etc.) and therapeutic drugs (cisplatin, carboplatin, paclitaxel, gefitinib, doxorubicin, etc.). Various strategies to prepare the size-controllable, stable, targeting and pH-responsive CaP nanocarriers have been extensively developed as the potential candidates in clinic. This review discusses the mostly recent developments in the design of calcium phosphate nanocarriers as drug delivery systems and therapeutic agents. Additionally, the advantage is unquestionably demonstrated and the obstacles are thoroughly examined in order to overcome future clinical issues.

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