Hyalocytes in Proliferative Vitreo-retinal Diseases

Overview

Journal Expert Rev Ophthalmol

Publisher Informa Healthcare

Specialty Ophthalmology

Date 2022 Dec 5

PMID 36466118

Authors

Charlotte H Jones

Wei Gui

Ricarda G Schumann

Stefaniya Boneva

Clemens Ak Lange

Koen van Overdam

Toco Yp Chui

Richard B Rosen

Michael Engelbert

J Sebag

Affiliations

Soon will be listed here.

Abstract

Introduction: Hyalocytes are sentinel macrophages residing within the posterior vitreous cortex anterior to the retinal inner limiting membrane (ILM). Following anomalous PVD and vitreoschisis, hyalocytes contribute to paucicellular (vitreo-macular traction syndrome, macular holes) and hypercellular (macular pucker, proliferative vitreo-retinopathy, proliferative diabetic vitreo-retinopathy) diseases.

Areas Covered: Studies of human tissues employing dark-field, phase, and electron microscopy; immunohistochemistry; and imaging of human hyalocytes.

Expert Opinion: Hyalocytes are important in early pathophysiology, stimulating cell migration and proliferation, as well as subsequent membrane contraction and vitreo-retinal traction. Targeting hyalocytes early could mitigate advanced disease. Ultimately, eliminating the role of vitreous and hyalocytes may prevent proliferative vitreo-retinal diseases entirely.

Citing Articles

Fibrotic Changes in Rhegmatogenous Retinal Detachment.

Harju N, Kauppinen A, Loukovaara S Int J Mol Sci. 2025; 26(3).

PMID: 39940795 PMC: 11817287. DOI: 10.3390/ijms26031025.

Short-Term Culture of Human Hyalocytes Retains Their Initial Phenotype and Displays Their Contraction Abilities.

Micera A, Balzamino B, Cosimi P, Esposito G, Ripandelli G, Rossi T Cells. 2024; 13(22).

PMID: 39594586 PMC: 11592754. DOI: 10.3390/cells13221837.

The multifaceted role of vitreous hyalocytes: Orchestrating inflammation, angiomodulation and erythrophagocytosis in proliferative diabetic retinopathy.

Boneva S, Wolf J, Jung M, Prinz G, Chui T, Jauch J J Neuroinflammation. 2024; 21(1):297.

PMID: 39543723 PMC: 11566480. DOI: 10.1186/s12974-024-03291-5.

Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body.

Rosmus D, Koch J, Hausmann A, Chiot A, Arnhold F, Masuda T J Neuroinflammation. 2024; 21(1):168.

PMID: 38961498 PMC: 11223341. DOI: 10.1186/s12974-024-03110-x.

Visualizing features with wide-field volumetric OCT angiography.

Hormel T, Liang G, Wei X, Guo Y, Gao M, Wang J Opt Express. 2024; 32(6):10329-10347.

PMID: 38571248 PMC: 11018334. DOI: 10.1364/OE.510640.

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