Exosomes As a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion

Overview

Journal Aging Dis

Specialty Geriatrics

Date 2022 Dec 5

PMID 36465167

Authors

Ziyu An

Jinfan Tian

Yue Liu

Xin Zhao

Xueyao Yang

Jingwen Yong

Libo Liu

Lijun Zhang

Wenjian Jiang

Xiantao Song

Hongjia Zhang

Affiliations

Soon will be listed here.

Abstract

Exosomes, which contain miRNA, have been receiving growing attention in cardiovascular therapy because of their role in mediating cell-cell communication, autophagy, apoptosis, inflammation, and angiogenesis. Several studies have suggested that miRNA derived from exosomes can be used to detect myocardial infarctions (MI) in patients. Basic research also suggests that exosomes could serve as a potential therapeutic target for treating acute myocardial infarction. Ischemia/reperfusion (IR) injury is associated with adverse cardiac events after acute MI. We aim to review the potential benefits and mechanisms of exosomes in treating MI and IR injury.

Citing Articles

Cardioprotective effects of hUCMSCs-Exosi-EGR1 MN patch in MI/RI by modulating oxidative stress and mitophagy.

Huang C, Zhang X, Wu S, Chang Q, Zheng Z, Xu J Mater Today Bio. 2025; 31:101500.

PMID: 39944530 PMC: 11815289. DOI: 10.1016/j.mtbio.2025.101500.

Aerobic exercise inhibits GSDME-dependent myocardial cell pyroptosis to protect ischemia-reperfusion injury.

Li Y, Wang X, Meng X, Xia C, Yang C, Wang J Mol Med. 2024; 30(1):273.

PMID: 39719560 PMC: 11668014. DOI: 10.1186/s10020-024-01048-7.

Neutrophil N1 polarization induced by cardiomyocyte-derived extracellular vesicle miR-9-5p aggravates myocardial ischemia/reperfusion injury.

Zhang Y, Li X, Dai Y, Han Y, Wei X, Wei G J Nanobiotechnology. 2024; 22(1):632.

PMID: 39415256 PMC: 11484374. DOI: 10.1186/s12951-024-02902-w.

Mesenchymal stem cell-derived exosomal mir-21-5p inhibits YAP1 expression and improves outcomes in myocardial infarction.

Ji Z, Wang C BMC Cardiovasc Disord. 2024; 24(1):547.

PMID: 39385107 PMC: 11465913. DOI: 10.1186/s12872-024-04197-z.

Therapeutic application of adipose-derived stromal vascular fraction in myocardial infarction.

Gareev I, Beylerli O, Ilyasova T, Ahmad A, Shi H, Chekhonin V iScience. 2024; 27(5):109791.

PMID: 38736548 PMC: 11088339. DOI: 10.1016/j.isci.2024.109791.

References

Carvalho E, Verma P, Hourigan K, Banerjee R . Myocardial infarction: stem cell transplantation for cardiac regeneration. Regen Med. 2015; 10(8):1025-43. DOI: 10.2217/rme.15.63. View

Zhang C, Shao K, Liu C, Li C, Yu B . Hypoxic preconditioning BMSCs-exosomes inhibit cardiomyocyte apoptosis after acute myocardial infarction by upregulating microRNA-24. Eur Rev Med Pharmacol Sci. 2019; 23(15):6691-6699. DOI: 10.26355/eurrev_201908_18560. View

Xiao C, Wang K, Xu Y, Hu H, Zhang N, Wang Y . Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of miR-125b. Circ Res. 2018; 123(5):564-578. DOI: 10.1161/CIRCRESAHA.118.312758. View

Golforoush P, Yellon D, Davidson S . Mouse models of atherosclerosis and their suitability for the study of myocardial infarction. Basic Res Cardiol. 2020; 115(6):73. PMC: 7704510. DOI: 10.1007/s00395-020-00829-5. View

Huang H, Xu Z, Qi Y, Zhang W, Zhang C, Jiang M . Exosomes from SIRT1-Overexpressing ADSCs Restore Cardiac Function by Improving Angiogenic Function of EPCs. Mol Ther Nucleic Acids. 2020; 21:737-750. PMC: 7412761. DOI: 10.1016/j.omtn.2020.07.007. View

Deng S, Zhou X, Ge Z, Song Y, Wang H, Liu X . Exosomes from adipose-derived mesenchymal stem cells ameliorate cardiac damage after myocardial infarction by activating S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization. Int J Biochem Cell Biol. 2019; 114:105564. DOI: 10.1016/j.biocel.2019.105564. View

Gnecchi M, He H, Liang O, Melo L, Morello F, Mu H . Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med. 2005; 11(4):367-8. DOI: 10.1038/nm0405-367. View

Wu Z, Cheng S, Wang S, Li W, Liu J . RETRACTED:BMSCs-derived exosomal microRNA-150-5p attenuates myocardial infarction in mice. Int Immunopharmacol. 2021; 93:107389. DOI: 10.1016/j.intimp.2021.107389. View

Xu H, Wang Z, Liu L, Zhang B, Li B . Exosomes derived from adipose tissue, bone marrow, and umbilical cord blood for cardioprotection after myocardial infarction. J Cell Biochem. 2019; 121(3):2089-2102. DOI: 10.1002/jcb.27399. View

10.

Eguchi S, Takefuji M, Sakaguchi T, Ishihama S, Mori Y, Tsuda T . Cardiomyocytes capture stem cell-derived, anti-apoptotic microRNA-214 via clathrin-mediated endocytosis in acute myocardial infarction. J Biol Chem. 2019; 294(31):11665-11674. PMC: 6682734. DOI: 10.1074/jbc.RA119.007537. View

11.

Arjmand B, Abedi M, Arabi M, Alavi-Moghadam S, Rezaei-Tavirani M, Hadavandkhani M . Regenerative Medicine for the Treatment of Ischemic Heart Disease; Status and Future Perspectives. Front Cell Dev Biol. 2021; 9:704903. PMC: 8461329. DOI: 10.3389/fcell.2021.704903. View

12.

Belien H, Evens L, Hendrikx M, Bito V, Bronckaers A . Combining stem cells in myocardial infarction: The road to superior repair?. Med Res Rev. 2021; 42(1):343-373. DOI: 10.1002/med.21839. View

13.

Eming S, Wynn T, Martin P . Inflammation and metabolism in tissue repair and regeneration. Science. 2017; 356(6342):1026-1030. DOI: 10.1126/science.aam7928. View

14.

Zhang N, Zhu J, Ma Q, Zhao Y, Wang Y, Hu X . Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair. Stem Cell Res Ther. 2020; 11(1):273. PMC: 7346506. DOI: 10.1186/s13287-020-01782-9. View

15.

Zhang Y, Hao Z, Wang P, Xia Y, Wu J, Xia D . Exosomes from human umbilical cord mesenchymal stem cells enhance fracture healing through HIF-1α-mediated promotion of angiogenesis in a rat model of stabilized fracture. Cell Prolif. 2019; 52(2):e12570. PMC: 6496165. DOI: 10.1111/cpr.12570. View

16.

Zheng M, Liu X, Han R, Yuan W, Sun K, Zhong J . Circulating exosomal long non-coding RNAs in patients with acute myocardial infarction. J Cell Mol Med. 2020; 24(16):9388-9396. PMC: 7417690. DOI: 10.1111/jcmm.15589. View

17.

Cao C, Wang B, Tang J, Zhao J, Guo J, Guo Q . Circulating exosomes repair endothelial cell damage by delivering miR-193a-5p. J Cell Mol Med. 2020; 25(4):2176-2189. PMC: 7882992. DOI: 10.1111/jcmm.16202. View

18.

Wang X, Zhu Y, Wu C, Liu W, He Y, Yang Q . Adipose-Derived Mesenchymal Stem Cells-Derived Exosomes Carry MicroRNA-671 to Alleviate Myocardial Infarction Through Inactivating the TGFBR2/Smad2 Axis. Inflammation. 2021; 44(5):1815-1830. PMC: 8460592. DOI: 10.1007/s10753-021-01460-9. View

19.

Maring J, Beez C, Falk V, Seifert M, Stamm C . Myocardial Regeneration via Progenitor Cell-Derived Exosomes. Stem Cells Int. 2018; 2017:7849851. PMC: 5733225. DOI: 10.1155/2017/7849851. View

20.

Zheng L, Li Z, Ling W, Zhu D, Feng Z, Kong L . Exosomes Derived from Dendritic Cells Attenuate Liver Injury by Modulating the Balance of Treg and Th17 Cells After Ischemia Reperfusion. Cell Physiol Biochem. 2018; 46(2):740-756. DOI: 10.1159/000488733. View