Stable Methylation Loci Are Associated with Systolic Blood Pressure in a Croatian Island Population

Overview

Journal Epigenomics

Specialty Genetics

Date 2022 Dec 1

PMID 36453021

Authors

Alexander C Sprague

Liang Niu

Roman Jandarov

Xiang Zhang

Ge Zhang

Aimin Chen

Jelena Sarac

Miran coklo

Sasa Missoni

Pavao Rudan

Scott M Langevin

Ranjan Deka

Affiliations

Soon will be listed here.

Abstract

The objective was to identify stable and dynamic DNA methylation loci associated with cardiometabolic traits among an adult population from the Croatian island of Hvar. An epigenome-wide association study was conducted using peripheral blood longitudinally collected at two time points 10 years apart via Infinium MethylationEPIC beadarray (n = 112). Stable and dynamic loci were identified using linear mixed models. Associations between cardiometabolic traits and loci were assessed using linear models. 22 CpG loci were significantly associated with systolic blood pressure. Twenty were stable and two were dynamic. Multiple genes may be involved in the determination of systolic blood pressure level via stable epigenetic programming, potentially established earlier in life.

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