The Effect of Body Mass Index on Neonatal Outcomes in Chinese Women with Polycystic Ovary Syndrome

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2022 Dec 1

PMID 36452898

Authors

Haiyan Guo

Bian Wang

Hongyuan Gao

Qianqian Zhu

Affiliations

Soon will be listed here.

Abstract

Aim: This study aimed to explore the effect of body mass index (BMI) on neonatal outcomes in patients with polycystic ovary syndrome following the frozen embryo transfer (FET).

Methods: This study included 1,676 singletons born from mothers with polycystic ovary syndrome (PCOS) after FET between 1 Jan 2007 and 31 Dec 2019. BMI was categorized into three groups: underweight (BMI less than 18.5 kg/m), normal weight (BMI between 18.5 and 24.9 kg/m), and overweight (BMI between 25.0 and 29.9 kg/m). Logistic regression models with generalized estimating equations were used for clustering by patients to explore the effect of BMI on neonatal outcomes.

Results: When compared to normal-weight mothers, the rate of large for gestational age (LGA) babies (adjusted odds ratio [aOR] 0.45, 95% confidence interval [95%CI] 0.22-0.93) significantly decreased for underweight mothers and significantly increased (aOR 1.82, 95%CI 1.38-2.41) for overweight mothers. The rate of high birth weight among infants from overweight mothers (aOR 1.75, 95%CI 1.15-2.65) was significantly higher than those from normal-weight mothers after adjusting for known confounding factors. The rate of small for gestational age (SGA) singleton (aOR 2.37, 95%CI 1.14-4.93) was lower among underweight mothers than normal-weight mothers.

Conclusion: Maternal underweight was a significant protective factor against LGA infants for singletons born from patients with PCOS after FET, whereas maternal overweight was an adverse factor for LGA infants.

Citing Articles

Higher pre-pregnancy body mass index was associated with adverse pregnancy and perinatal outcomes in women with polycystic ovary syndrome after a freeze-all strategy: A historical cohort study.

Hu X, Yan E, Peng W, Zhou Y, Jin L, Qian K Acta Obstet Gynecol Scand. 2024; 103(5):884-896.

PMID: 38217337 PMC: 11019514. DOI: 10.1111/aogs.14771.

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