Impaired Health-Related Quality of Life in Brazilian Children with Chronic Abdominal Pain: A Cross-Sectional Study

Overview

Journal Pediatr Gastroenterol Hepatol Nutr

Date 2022 Dec 1

PMID 36451694

Authors

Carine Dias Ferreira de Jesus

Mary de Assis Carvalho

Nilton Carlos Machado

Affiliations

Soon will be listed here.

Abstract

Purpose: We compared the health-related quality of life (HRQOL) of children and adolescents with functional abdominal pain disorders (FAPDs) and organic abdominal pain disorders (ORGDs).

Methods: This was a single-center, cross-sectional, observational study. The PedsQL 4.0 generic cores scales parent proxy-report was administered to parents/caregivers of 130 and 56 pediatric patients with FAPDs and ORGDs respectively on their first visit. The self-reported pain intensity in the patients was assessed using a visual analog scale (VAS) and facial affective scale (FAS).

Results: Irritable bowel syndrome was the most prevalent FAPDs, and the most prevalent ORGDs were reflux esophagitis (41.1%) and gastritis associated with (21.4%). There was no difference in HRQOL among patients diagnosed with ORGDs and FAPDs (>0.05). Patients with ORGDs and FAPDs had lower HRQOL Scale scores than healthy Brazilian and American children's references, with a high proportion of children at risk for impaired HRQOL (<0.0001). There was no difference in the VAS and the FAS scores between the ORGDs and the FAPDs. FAPDs had a higher prevalence of girls' and couples' disagreement (<0.02), although poor school performance (<0.0007) and bullying (<0.01) were higher in patients with ORGD.

Conclusion: This study revealed that there was a difference in impaired HRQOL between patients with ORGDs and FAPDs. Thus, considering the high prevalence of chronic abdominal pain in children, a well-founded treatment plan is necessary for a multidisciplinary cognitive-behavioral Pain management program.

References

APLEY J, Naish N . Recurrent abdominal pains: a field survey of 1,000 school children. Arch Dis Child. 1958; 33(168):165-70. PMC: 2012205. DOI: 10.1136/adc.33.168.165. View

Palermo T, Long A, Lewandowski A, Drotar D, Quittner A, Walker L . Evidence-based assessment of health-related quality of life and functional impairment in pediatric psychology. J Pediatr Psychol. 2008; 33(9):983-96. PMC: 2543105. DOI: 10.1093/jpepsy/jsn038. View

Warschburger P, Hanig J, Friedt M, Posovszky C, Schier M, Calvano C . Health-related quality of life in children with abdominal pain due to functional or organic gastrointestinal disorders. J Pediatr Psychol. 2013; 39(1):45-54. DOI: 10.1093/jpepsy/jst070. View

Korterink J, Diederen K, Benninga M, Tabbers M . Epidemiology of pediatric functional abdominal pain disorders: a meta-analysis. PLoS One. 2015; 10(5):e0126982. PMC: 4439136. DOI: 10.1371/journal.pone.0126982. View

Gulewitsch M, Enck P, Schwille-Kiuntke J, Weimer K, Schlarb A . Rome III criteria in parents' hands: pain-related functional gastrointestinal disorders in community children and associations with somatic complaints and mental health. Eur J Gastroenterol Hepatol. 2013; 25(10):1223-9. DOI: 10.1097/MEG.0b013e328364b55d. View

McGrath P, Walco G, Turk D, Dworkin R, Brown M, Davidson K . Core outcome domains and measures for pediatric acute and chronic/recurrent pain clinical trials: PedIMMPACT recommendations. J Pain. 2008; 9(9):771-83. DOI: 10.1016/j.jpain.2008.04.007. View

. Chronic abdominal pain in children. Pediatrics. 2005; 115(3):812-5. DOI: 10.1542/peds.2004-2497. View

Varni J, Lane M, Burwinkle T, Fontaine E, Youssef N, Schwimmer J . Health-related quality of life in pediatric patients with irritable bowel syndrome: a comparative analysis. J Dev Behav Pediatr. 2006; 27(6):451-8. DOI: 10.1097/00004703-200612000-00001. View

Youssef N, Murphy T, Langseder A, Rosh J . Quality of life for children with functional abdominal pain: a comparison study of patients' and parents' perceptions. Pediatrics. 2006; 117(1):54-9. DOI: 10.1542/peds.2005-0114. View

10.

Di Lorenzo C, Colletti R, Lehmann H, Boyle J, Gerson W, Hyams J . Chronic abdominal pain in children: a clinical report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005; 40(3):245-8. DOI: 10.1097/01.mpg.0000155367.44628.21. View

11.

Correa Silva R, Machado N, Carvalho M, Rodrigues M . Helicobacter pylori infection is high in paediatric nonulcer dyspepsia but not associated with specific gastrointestinal symptoms. Acta Paediatr. 2016; 105(5):e228-31. DOI: 10.1111/apa.13347. View

12.

Lundell L, Dent J, Bennett J, Blum A, Armstrong D, Galmiche J . Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut. 1999; 45(2):172-80. PMC: 1727604. DOI: 10.1136/gut.45.2.172. View

13.

. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995; 854:1-452. View

14.

Lisman-van Leeuwen Y, Spee L, Benninga M, Bierma-Zeinstra S, Berger M . Prognosis of abdominal pain in children in primary care--a prospective cohort study. Ann Fam Med. 2013; 11(3):238-44. PMC: 3659140. DOI: 10.1370/afm.1490. View

15.

Assa A, Ish-Tov A, Rinawi F, Shamir R . School Attendance in Children With Functional Abdominal Pain and Inflammatory Bowel Diseases. J Pediatr Gastroenterol Nutr. 2015; 61(5):553-7. DOI: 10.1097/MPG.0000000000000850. View

16.

von Baeyer C . Children's self-report of pain intensity: what we know, where we are headed. Pain Res Manag. 2009; 14(1):39-45. PMC: 2706563. DOI: 10.1155/2009/259759. View

17.

Spee L, Lisman-van Leeuwen Y, Benninga M, Bierma-Zeinstra S, Berger M . Prevalence, characteristics, and management of childhood functional abdominal pain in general practice. Scand J Prim Health Care. 2013; 31(4):197-202. PMC: 3860295. DOI: 10.3109/02813432.2013.844405. View

18.

Greenley R, Kunz J, Schurman J, Swanson E . Abdominal pain and health related quality of life in pediatric inflammatory bowel disease. J Pediatr Psychol. 2012; 38(1):63-71. DOI: 10.1093/jpepsy/jss097. View

19.

Campo J, Bridge J, Lucas A, Savorelli S, Walker L, Di Lorenzo C . Physical and emotional health of mothers of youth with functional abdominal pain. Arch Pediatr Adolesc Med. 2007; 161(2):131-7. DOI: 10.1001/archpedi.161.2.131. View

20.

Gold J, Mahrer N, Yee J, Palermo T . Pain, fatigue, and health-related quality of life in children and adolescents with chronic pain. Clin J Pain. 2009; 25(5):407-12. PMC: 2844257. DOI: 10.1097/AJP.0b013e318192bfb1. View