Revealing Joseon Period People's Single Nucleotide Polymorphism Associated with Lactase Gene by Ancient DNA Analysis of Human Remains from Archaeological Sites in Korea

Overview

Journal Anat Cell Biol

Specialty Anatomy & Histology

Date 2022 Nov 30

PMID 36450657

Authors

Chang Seok Oh

Myeung Ju Kim

Yi-Suk Kim

Sori Min

Kyong Taek Oh

Soong Deok Lee

Dong Hoon Shin

Affiliations

Soon will be listed here.

Abstract

Lactase non-persistence (LNP), one of the causes of lactose intolerance, is related to lactase gene associated single nucleotide polymorphisms (SNPs). Since the frequency of LNP varies by ethnic group and country, the research to reveal the presence or absence of LNP for specific people has been conducted worldwide. However, in East Asia, the study of lactase gene associated SNPs have not been sufficiently examined so far using ancient human specimens from archaeological sites. In our study of Joseon period human remains (n=14), we successfully revealed genetic information of lactase gene associated SNPs (rs1679771596, rs41525747, rs4988236, rs4988235, rs41380347, rs869051967, rs145946881 and rs182549), further confirming that as for eight SNPs, the pre-modern Korean people had a lactase non-persistent genotype. Our report contributes to the establishment of LNP associated SNP analysis technique that can be useful in forthcoming studies on human bones and mummy samples from East Asian archaeological sites.

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