Biological Characterization, Properties, and Clinical Use of a Novel Homeopathic Antiseptic Oral Recovery Kit: A Narrative Review

Overview

Journal Oral Health Prev Dent

Date 2022 Nov 30

PMID 36448277

Authors

Nathan E Estrin

Georgios E Romanos

Walter Tatch

Michael Pikos

Richard J Miron

Affiliations

Soon will be listed here.

Abstract

Most available antiseptic solutions have strong antibacterial effects, but many also possess major cytotoxic effects on gingival fibroblasts, osteoblasts, osteoprogenitor cells, and/or epithelial cells. A novel VEGA Oral Care Recovery Kit (StellaLife) consisting of 16 active ingredients that are monographed in the Homeopathic Pharmacopeia of the United States (HPUS) has gained tremendous momentum as a replacement for more cytotoxic oral rinses such as chlorhexidine. While accumulating evidence has thus far supported its use, little of the gathered data have fully described the properties of the oral formulation. Therefore, the aim of the present review article was 3-fold. First, a biological characterization regarding the active ingredients found in StellaLife Recovery Kit including their biological properties was assessed in 4 predominant categories; 1) antimicrobial resistance, 2) accelerated wound healing, 3) pain management control, and 4) anti-cancer properties. The second aim of this review article was to assess both fundamental and clinical research to date comparing VEGA oral rinse (StellaLife) to the more commonly utilized CHX for differences regarding their effect on decreasing bacterial loads as well as cell viability, survival, proliferation, and expression of both regenerative cytokines and inflammatory markers. Lastly, clinical case examples are presented describing the use of StellaLife remedies in a variety of clinical situations. These include but are not limited to wisdom-tooth extraction, extraction site management, dental implants and ridge augmentation, soft-tissue grafting procedures, frenectomies, and also temporary relief of dry sockets, dry mouth, aphthous ulcers, mucositis, lichen planus, among others. In summary, findings from the present review article provide evidence from basic laboratory experiments that validate clinical studies supporting the use of the StellaLife oral rinse regarding its superior biocompatibility and wound healing properties when compared to common antiseptic solutions such as CHX.

References

Sedghi L, DiMassa V, Harrington A, Lynch S, Kapila Y . The oral microbiome: Role of key organisms and complex networks in oral health and disease. Periodontol 2000. 2021; 87(1):107-131. PMC: 8457218. DOI: 10.1111/prd.12393. View

Ortiz M, Fernandez-Martinez E, Soria-Jasso L, Lucas-Gomez I, Villagomez-Ibarra R, Gonzalez-Garcia M . Isolation, identification and molecular docking as cyclooxygenase (COX) inhibitors of the main constituents of Matricaria chamomilla L. extract and its synergistic interaction with diclofenac on nociception and gastric damage in rats. Biomed Pharmacother. 2016; 78:248-256. DOI: 10.1016/j.biopha.2016.01.029. View

Jakubovics N, Goodman S, Mashburn-Warren L, Stafford G, Cieplik F . The dental plaque biofilm matrix. Periodontol 2000. 2021; 86(1):32-56. PMC: 9413593. DOI: 10.1111/prd.12361. View

Sarkar P, Acharyya S, Banerjee A, Patra A, Thankamani K, Koley H . Intracellular, biofilm-inhibitory and membrane-damaging activities of nimbolide isolated from Azadirachta indica A. Juss (Meliaceae) against meticillin-resistant Staphylococcus aureus. J Med Microbiol. 2016; 65(10):1205-1214. DOI: 10.1099/jmm.0.000343. View

Magnani P, Conforti A, Zanolin E, Marzotto M, Bellavite P . Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice. Psychopharmacology (Berl). 2010; 210(4):533-45. PMC: 2877813. DOI: 10.1007/s00213-010-1855-2. View

Laugisch O, Ramseier C, Salvi G, Hagi T, Burgin W, Eick S . Effects of two different post-surgical protocols including either 0.05 % chlorhexidine herbal extract or 0.1 % chlorhexidine on post-surgical plaque control, early wound healing and patient acceptance following standard periodontal surgery and.... Clin Oral Investig. 2016; 20(8):2175-2183. DOI: 10.1007/s00784-016-1713-7. View

Gottschalk A, Smith D . New concepts in acute pain therapy: preemptive analgesia. Am Fam Physician. 2001; 63(10):1979-84. View

Sartore-Bianchi A, Ricotta R, Cerea G, Maugeri M, Siena S . Rationale and clinical results of multi-target treatments in oncology. Int J Biol Markers. 2017; 22(4):77-87. DOI: 10.1177/17246008070221s410. View

Darveau R, Curtis M . Oral biofilms revisited: A novel host tissue of bacteriological origin. Periodontol 2000. 2021; 86(1):8-13. DOI: 10.1111/prd.12374. View

10.

Sawada K, Fujioka-Kobayashi M, Kobayashi E, Schaller B, Miron R . Effects of Antiseptic Solutions Commonly Used in Dentistry on Bone Viability, Bone Morphology, and Release of Growth Factors. J Oral Maxillofac Surg. 2015; 74(2):247-54. DOI: 10.1016/j.joms.2015.09.029. View

11.

Paul R, Prasad M, Sah N . Anticancer biology of Azadirachta indica L (neem): a mini review. Cancer Biol Ther. 2011; 12(6):467-76. DOI: 10.4161/cbt.12.6.16850. View

12.

Gupta S, Prasad S, Tyagi A, Kunnumakkara A, Aggarwal B . Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis. Phytomedicine. 2017; 34:14-20. DOI: 10.1016/j.phymed.2017.07.001. View

13.

Joseph S, Curtis M . Microbial transitions from health to disease. Periodontol 2000. 2021; 86(1):201-209. DOI: 10.1111/prd.12377. View

14.

Spahr A, Divnic-Resnik T . Impact of health and lifestyle food supplements on periodontal tissues and health. Periodontol 2000. 2022; 90(1):146-175. PMC: 9804634. DOI: 10.1111/prd.12455. View

15.

Alves A, Goncalves J, Cruz J, Antonio M Araujo D . Evaluation of the sesquiterpene (-)-alpha-bisabolol as a novel peripheral nervous blocker. Neurosci Lett. 2010; 472(1):11-5. DOI: 10.1016/j.neulet.2010.01.042. View

16.

Leibowitz B, Yu J . Mitochondrial signaling in cell death via the Bcl-2 family. Cancer Biol Ther. 2010; 9(6):417-22. PMC: 2874116. DOI: 10.4161/cbt.9.6.11392. View

17.

Bernardi A, Teixeira C . The properties of chlorhexidine and undesired effects of its use in endodontics. Quintessence Int. 2015; 46(7):575-82. DOI: 10.3290/j.qi.a33934. View

18.

Zubair M, Nybom H, Lindholm C, Brandner J, Rumpunen K . Promotion of wound healing by Plantago major L. leaf extracts--ex-vivo experiments confirm experiences from traditional medicine. Nat Prod Res. 2015; 30(5):622-4. DOI: 10.1080/14786419.2015.1034714. View

19.

Rutkow L, Vernick J . Emergency Legal Authority and the Opioid Crisis. N Engl J Med. 2017; 377(26):2512-2514. DOI: 10.1056/NEJMp1710862. View

20.

Conway D, Purkayastha M, Chestnutt I . The changing epidemiology of oral cancer: definitions, trends, and risk factors. Br Dent J. 2018; 225(9):867-873. DOI: 10.1038/sj.bdj.2018.922. View