The Effect of Temperament on the Association Between Pre-treatment Anxiety and Chemotherapy-Related Symptoms in Patients With Breast Cancer

Overview

Journal Psychiatry Investig

Specialty Psychiatry

Date 2022 Nov 29

PMID 36444158

Authors

Jung-In Choi

Sanghyup Jung

Gyu Han Oh

Kyung-Lak Son

Kwang-Min Lee

Dooyoung Jung

Tae-Yong Kim

Seock-Ah Im

Kyung-Hun Lee

Min-Sup Shin

Bong-Jin Hahm

Chan-Woo Yeom

Affiliations

Soon will be listed here.

Abstract

Objective: Pre-treatment anxiety (PA) before chemotherapy increases complaints of chemotherapy-related symptoms (CRS). The results on the association have been inconsistent, and the effect of temperament remains unclear. We aimed to determine whether PA is a risk factor for CRS and the effect of differing temperaments on CRS.

Methods: This prospective study comprised 176 breast cancer patients awaiting adjuvant chemotherapy post-surgery. We assessed CRS, PA, and temperament using the MD Anderson Symptom Inventory (MDASI), the Hospital Anxiety and Depression Scale, and the short form of the Temperament and Character Inventory-Revised, respectively. The MDASI was re-administered three weeks after the first chemo-cycle.

Results: PA showed weak positive correlation with several CRS after the first cycle; no CRS was significantly associated with PA when pre-treatment depressive symptoms and baseline CRS were adjusted in multiple regression analysis. Moderation model analysis indicated that the PA effect on several CRS, including pain, insomnia, anorexia, dry mouth, and vomiting, was moderated by harm avoidance (HA) but not by other temperament dimensions. In particular, PA was positively associated with CRS in patients with low HA.

Conclusion: The results in patients with low HA indicate that more attention to PA in patients with confident and optimistic temperaments is necessary.

Citing Articles

Using temperament and character dimensions (TCI) to analyze the personality profiles of adults and older adults with cancer managed in outpatient settings.

Vespa A, Giulietti M, Fabbietti P, Di Rosa M, Gattafoni P, Berardi R Front Psychol. 2024; 14:1289093.

PMID: 38288360 PMC: 10822941. DOI: 10.3389/fpsyg.2023.1289093.

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