Physiological Roles of β-amyloid in Regulating Synaptic Function: Implications for AD Pathophysiology

Overview

Journal Neurosci Bull

Specialty Neurology

Date 2022 Nov 28

PMID 36443453

Authors

Wenwen Cai

Linxi Li

Shaoming Sang

Xiaoli Pan

Chunjiu Zhong

Affiliations

Soon will be listed here.

Abstract

The physiological functions of endogenous amyloid-β (Aβ), which plays important role in the pathology of Alzheimer's disease (AD), have not been paid enough attention. Here, we review the multiple physiological effects of Aβ, particularly in regulating synaptic transmission, and the possible mechanisms, in order to decipher the real characters of Aβ under both physiological and pathological conditions. Some worthy studies have shown that the deprivation of endogenous Aβ gives rise to synaptic dysfunction and cognitive deficiency, while the moderate elevation of this peptide enhances long term potentiation and leads to neuronal hyperexcitability. In this review, we provide a new view for understanding the role of Aβ in AD pathophysiology from the perspective of physiological meaning.

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