Application of I-MIBG Myocardial Maximum Standardized Uptake Value to Characterize Cardiac Function in Patients with Pheochromocytoma: Comparison with Echocardiography

Overview

Journal Jpn J Radiol

Publisher Springer

Specialty Radiology

Date 2022 Nov 28

PMID 36441441

Authors

Masatoyo Nakajo

Yoshihisa Horizoe

Kodai Kawaji

Megumi Jinguji

Atsushi Tani

Yoshihiko Fukukura

Mitsuru Ohishi

Takashi Yoshiura

Affiliations

Soon will be listed here.

Abstract

Purpose: This study examined the usefulness of the maximum standardized uptake value (SUVmax) of myocardial [I]-metaiodobenzylguanidine ([I]-MIBG) to characterize myocardial function by comparing it with echocardiographic parameters in patients with pheochromocytoma.

Materials And Methods: This study included 18 patients with pheochromocytoma who underwent both planar and [I]-MIBG single-photon emission computed tomography/computed tomography scans and echocardiography before surgery. Myocardial [I]-MIBG visibility and SUVmax were compared with echocardiographic parameters related to systolic and diastolic functions. The Mann-Whitney U test, Fisher exact test, or Spearman rank correlation assessed differences or relationships between two quantitative variables.

Results: On visual analysis, 6 patients showed normal myocardial [I]-MIBG uptake, whereas 12 patients showed decreased myocardial [I]-MIBG uptake. No patients showed systolic dysfunction. A significant difference was observed in the incidence of diastolic dysfunction between the groups with normal and decreased uptake (p = 0.009), and left ventricular (LV) diastolic dysfunction was observed in 9 (75%) of 12 patients with decreased myocardial uptake. The myocardial SUVmax was significantly lower in 9 patients with LV diastolic dysfunction than in 9 patients with normal cardiac function (1.67 ± 0.37 vs. 3.03 ± 1.38, p = 0.047). Myocardial SUVmax was positively correlated with septal e' (early diastolic velocity of septal mitral annulus) (ρ = 0.51, p = 0.031) and negatively correlated with the septal E/e' ratio (early mitral E-velocity to early diastolic velocity of septal mitral annulus; ρ = - 0.64, p = 0.004), respectively.

Conclusions: LV diastolic dysfunction was inversely related to myocardial [I]-MIBG uptake. Myocardial [I]-MIBG SUVmax may be useful for characterizing cardiac function in patients with pheochromocytoma. Second abstract. The semiquantitative analysis using the myocardial SUVmax in I-MIBG SPECT/CT was found to be potentially useful for characterizing cardiac function in patients with pheochromocytoma.

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