The Effect of Extracellular Vesicles on Thrombosis

Overview

Journal J Cardiovasc Transl Res

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2022 Nov 28

PMID 36441349

Authors

Youfu He

Qiang Wu

Affiliations

Soon will be listed here.

Abstract

The risk of cardiovascular events caused by acute thrombosis is high, including acute myocardial infarction, acute stroke, acute pulmonary embolism, and deep vein thrombosis. In this review, we summarize the roles of extracellular vesicles of different cellular origins in various cardiovascular events associated with acute thrombosis, as described in the current literature, to facilitate the future development of a precise therapy for thrombosis caused by such vesicles. We hope that our review will indicate a new horizon in the field of cardiovascular research with regard to the treatment of acute thrombosis, especially targeting thrombosis caused by extracellular vesicles secreted by individual cells. As more emerging technologies are being developed, new diagnostic and therapeutic strategies related to EVs are expected to be identified for related diseases in the future.

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References

Wilkerson W, Sane D . Aging and thrombosis. Semin Thromb Hemost. 2003; 28(6):555-68. DOI: 10.1055/s-2002-36700. View

Martinod K, Wagner D . Thrombosis: tangled up in NETs. Blood. 2013; 123(18):2768-76. PMC: 4007606. DOI: 10.1182/blood-2013-10-463646. View

Becker R, Sexton T, Smyth S . Translational Implications of Platelets as Vascular First Responders. Circ Res. 2018; 122(3):506-522. PMC: 5808568. DOI: 10.1161/CIRCRESAHA.117.310939. View

Fuentes E, Palomo I . Role of oxidative stress on platelet hyperreactivity during aging. Life Sci. 2016; 148:17-23. DOI: 10.1016/j.lfs.2016.02.026. View

Gistera A, Hansson G . The immunology of atherosclerosis. Nat Rev Nephrol. 2017; 13(6):368-380. DOI: 10.1038/nrneph.2017.51. View

Lepropre S, Kautbally S, Octave M, Ginion A, Onselaer M, Steinberg G . AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation. Blood. 2018; 132(11):1180-1192. PMC: 6238154. DOI: 10.1182/blood-2018-02-831503. View

Ismail N, Wang Y, Dakhlallah D, Moldovan L, Agarwal K, Batte K . Macrophage microvesicles induce macrophage differentiation and miR-223 transfer. Blood. 2012; 121(6):984-95. PMC: 3567345. DOI: 10.1182/blood-2011-08-374793. View

Klingeborn M, Dismuke W, Bowes Rickman C, Stamer W . Roles of exosomes in the normal and diseased eye. Prog Retin Eye Res. 2017; 59:158-177. PMC: 5537591. DOI: 10.1016/j.preteyeres.2017.04.004. View

Said A, Doctor A . Influence of red blood cell-derived microparticles upon vasoregulation. Blood Transfus. 2017; 15(6):522-534. PMC: 5649961. DOI: 10.2450/2017.0353-16. View

10.

Biswas A, Acharyya S . Understanding cachexia in the context of metastatic progression. Nat Rev Cancer. 2020; 20(5):274-284. DOI: 10.1038/s41568-020-0251-4. View

11.

Lucien F, Lac V, Billadeau D, Borgida A, Gallinger S, Leong H . Glypican-1 and glycoprotein 2 bearing extracellular vesicles do not discern pancreatic cancer from benign pancreatic diseases. Oncotarget. 2019; 10(10):1045-1055. PMC: 6383691. DOI: 10.18632/oncotarget.26620. View

12.

Bordanaba-Florit G, Royo F, Kruglik S, Falcon-Perez J . Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles. Nat Protoc. 2021; 16(7):3163-3185. DOI: 10.1038/s41596-021-00551-z. View

13.

Karimi N, Dalirfardouei R, Dias T, Lotvall J, Lasser C . Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma - Contributions of platelet extracellular vesicles in plasma samples. J Extracell Vesicles. 2022; 11(5):e12213. PMC: 9077141. DOI: 10.1002/jev2.12213. View

14.

Spectre G, Mobarrez F, Stalesen R, Ostenson C, Varon D, Wallen H . Meal intake increases circulating procoagulant microparticles in patients with type 1 and type 2 diabetes mellitus. Platelets. 2018; 30(3):348-355. DOI: 10.1080/09537104.2018.1445837. View

15.

Varon D, Shai E . Platelets and their microparticles as key players in pathophysiological responses. J Thromb Haemost. 2015; 13 Suppl 1:S40-6. DOI: 10.1111/jth.12976. View

16.

Thushara R, Hemshekhar M, Basappa , Kemparaju K, Rangappa K, Girish K . Biologicals, platelet apoptosis and human diseases: An outlook. Crit Rev Oncol Hematol. 2014; 93(3):149-58. DOI: 10.1016/j.critrevonc.2014.11.002. View

17.

Burnouf T, Goubran H, Chou M, Devos D, Radosevic M . Platelet microparticles: detection and assessment of their paradoxical functional roles in disease and regenerative medicine. Blood Rev. 2014; 28(4):155-66. DOI: 10.1016/j.blre.2014.04.002. View

18.

Ponomareva A, Nevzorova T, Mordakhanova E, Andrianova I, Rauova L, Litvinov R . Intracellular origin and ultrastructure of platelet-derived microparticles. J Thromb Haemost. 2017; 15(8):1655-1667. PMC: 5657319. DOI: 10.1111/jth.13745. View

19.

Owens 3rd A, Mackman N . Microparticles in hemostasis and thrombosis. Circ Res. 2011; 108(10):1284-97. PMC: 3144708. DOI: 10.1161/CIRCRESAHA.110.233056. View

20.

Wei H, Davies J, Harper M . 2-Aminoethoxydiphenylborate (2-APB) inhibits release of phosphatidylserine-exposing extracellular vesicles from platelets. Cell Death Discov. 2020; 6:10. PMC: 7051957. DOI: 10.1038/s41420-020-0244-9. View