Tangled Relationship Between Insulin Resistance and Microalbuminuria in Children with Obesity

Overview

Journal World J Clin Pediatr

Publisher Baishideng Publishing Group

Date 2022 Nov 28

PMID 36439903

Authors

Alberto Maria Colasante

Mario Bartiromo

Michele Nardolillo

Stefano Guarino

Pierluigi Marzuillo

Giuseppe Salvatore R C Mangoni di S Stefano

Emanuele Miraglia Del Giudice

Anna Di Sessa

Affiliations

Soon will be listed here.

Abstract

Childhood obesity represents a complex disease with a well-known cardiometabolic burden including fatty liver, type 2 diabetes, metabolic syndrome, and cardiovascular disease. From a pathogenic point of view, insulin resistance (IR) represents the key factor underlying the spectrum of these obesity consequences. As observed in adults, recent data supported the occurrence of microalbuminuria (MA) as marker of early kidney dysfunction and its potential link with cardiometabolic factors also in children with obesity. In fact, a well-documented pathophysiological hypothesis both in adults and children supported an intimate correlation with the major feature of obesity such as IR through the influence of insulin on renal hemodynamics. Based on the clinical and prognostic relevance of this relationship in daily practice (including an increased risk of chronic kidney disease development overtime), more scientific attention needs to be paid to the evaluation of early kidney damage in children with obesity. In this paper, we attempt to address three debated questions regarding the intriguing liaison between IR and MA in children with obesity: (1) What is the prevalence of pediatric MA? (2) What is the state of art of MA in children with obesity? and (3) Is there a link between IR and MA in children with obesity?

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