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Application Basis of Combining Antiangiogenic Therapy with Radiotherapy and Immunotherapy in Cancer Treatment

Overview
Journal Front Oncol
Specialty Oncology
Date 2022 Nov 28
PMID 36439496
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Abstract

How to further optimize the combination of radiotherapy and immunotherapy is among the current hot topics in cancer treatment. In addition to adopting the preferred dose-fractionation of radiotherapy or the regimen of immunotherapy, it is also very promising to add antiangiogenic therapy to this combination. We expound the application basis of cancer radiotherapy combined with immunotherapy and antiangiogenic therapy.

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References
1.
Manegold P, Paringer C, Kulka U, Krimmel K, Eichhorn M, Wilkowski R . Antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer. Clin Cancer Res. 2008; 14(3):892-900. DOI: 10.1158/1078-0432.CCR-07-0955. View

2.
Willett C, Kozin S, Duda D, Tomaso E, Kozak K, Boucher Y . Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice. Semin Oncol. 2006; 33(5 Suppl 10):S35-40. PMC: 2686124. DOI: 10.1053/j.seminoncol.2006.08.007. View

3.
Gabrilovich D, Nagaraj S . Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009; 9(3):162-74. PMC: 2828349. DOI: 10.1038/nri2506. View

4.
Jain R . Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005; 307(5706):58-62. DOI: 10.1126/science.1104819. View

5.
Dewhirst M, Cao Y, Moeller B . Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer. 2008; 8(6):425-37. PMC: 3943205. DOI: 10.1038/nrc2397. View