Dietary Zinc Intake and Mortality in Patients with Intestinal-type Gastric Cancer: A Prospective Cohort Study in Korea

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Nov 28

PMID 36439423

Authors

Jung Hyun Kwak

Chan Hyuk Park

Chang Soo Eun

Dong Soo Han

Yong Sung Kim

Kyu Sang Song

Bo Youl Choi

Hyun Ja Kim

Affiliations

Soon will be listed here.

Abstract

Purpose: Current evidence regarding the association between zinc intake and gastric cancer (GC)-specific survival in patients with intestinal-type GC is lacking. Therefore, this cohort study investigated the association between zinc intake and GC mortality through follow-up on GC death among patients with intestinal-type GC and whether these effects differ according to the source of zinc intake.

Methods: A total of 185 patients with intestinal-type GC were enrolled from two hospitals between 2002 and 2006. Their survival or death was prospectively followed up until December 31, 2016, through a review of medical records and telephone surveys.

Results: A total of 178 patients were included and analyzed. The median follow-up period was 7.3 years. In the fully adjusted models, the highest tertile of total zinc intake showed a significantly lower GC mortality than the lowest tertile (hazard ratio, 0.22; 95% confidence interval: 0.08-0.64). In addition, the tertile of total zinc intake showed a dose-response association with GC mortality (p=0.015). Analysis of the source of zinc intake revealed that when zinc intake from staples (rice and noodles), animal, and plant food sources were combined, the results were similar to those of total zinc intake and GC mortality.

Conclusion: Zinc intake through various foods may be effective in reducing GC mortality by achieving balance with other nutrients. Our results suggest that zinc improves the survival of patients with intestinal-type GC in Korea.

Citing Articles

The role of metal ions in the occurrence, progression, drug resistance, and biological characteristics of gastric cancer.

Xiao P, Li C, Liu Y, Gao Y, Liang X, Liu C Front Pharmacol. 2024; 15:1333543.

PMID: 38370477 PMC: 10869614. DOI: 10.3389/fphar.2024.1333543.

References

Arulselvan P, Fard M, Tan W, Gothai S, Fakurazi S, Norhaizan M . Role of Antioxidants and Natural Products in Inflammation. Oxid Med Cell Longev. 2016; 2016:5276130. PMC: 5075620. DOI: 10.1155/2016/5276130. View

MONSEN E, Hallberg L, LAYRISSE M, HEGSTED D, Cook J, Mertz W . Estimation of available dietary iron. Am J Clin Nutr. 1978; 31(1):134-41. DOI: 10.1093/ajcn/31.1.134. View

Shi Z, Chu A, Zhen S, Taylor A, Dai Y, Riley M . Association between dietary zinc intake and mortality among Chinese adults: findings from 10-year follow-up in the Jiangsu Nutrition Study. Eur J Nutr. 2017; 57(8):2839-2846. DOI: 10.1007/s00394-017-1551-7. View

Dhawan D, Chadha V . Zinc: a promising agent in dietary chemoprevention of cancer. Indian J Med Res. 2011; 132:676-82. PMC: 3102454. View

Pelucchi C, Tramacere I, Bertuccio P, Tavani A, Negri E, La Vecchia C . Dietary intake of selected micronutrients and gastric cancer risk: an Italian case-control study. Ann Oncol. 2008; 20(1):160-5. DOI: 10.1093/annonc/mdn536. View

Harrison L, Zhang Z, Karpeh M, Sun M, Kurtz R . The role of dietary factors in the intestinal and diffuse histologic subtypes of gastric adenocarcinoma: a case-control study in the U.S. Cancer. 1997; 80(6):1021-8. View

Cao L, Wang S, Zhang Y, Wong K, Nakatsu G, Wang X . Zinc-finger protein 471 suppresses gastric cancer through transcriptionally repressing downstream oncogenic PLS3 and TFAP2A. Oncogene. 2018; 37(26):3601-3616. PMC: 6021371. DOI: 10.1038/s41388-018-0220-5. View

Hunt J . Bioavailability of iron, zinc, and other trace minerals from vegetarian diets. Am J Clin Nutr. 2003; 78(3 Suppl):633S-639S. DOI: 10.1093/ajcn/78.3.633S. View

Pretorius B, Schonfeldt H, Hall N . Total and haem iron content lean meat cuts and the contribution to the diet. Food Chem. 2015; 193:97-101. DOI: 10.1016/j.foodchem.2015.02.109. View

10.

Epstein M, Kasperzyk J, Andren O, Giovannucci E, Wolk A, Hakansson N . Dietary zinc and prostate cancer survival in a Swedish cohort. Am J Clin Nutr. 2011; 93(3):586-93. PMC: 3041600. DOI: 10.3945/ajcn.110.004804. View

11.

Song S, Kim B, Pang Y, Kim O, Lee J . Reproducibility of a food frequency questionnaire: Korea Nurses' Health Study. Nutr Res Pract. 2022; 16(1):106-119. PMC: 8784265. DOI: 10.4162/nrp.2022.16.1.106. View

12.

Hadi V, Pahlavani N, Malekahmadi M, Nattagh-Eshtivani E, Gholizadeh Navashenaq J, Hadi S . in controlling Type 2 diabetes, cardiovascular, and rheumatoid arthritis diseases: Molecular aspects. J Res Med Sci. 2021; 26:20. PMC: 8240544. DOI: 10.4103/jrms.JRMS_236_20. View

13.

Livingstone C . Zinc: physiology, deficiency, and parenteral nutrition. Nutr Clin Pract. 2015; 30(3):371-82. DOI: 10.1177/0884533615570376. View

14.

Lim H, Cho G, Kim S . Evaluation of nutrient intake and diet quality of gastric cancer patients in Korea. Nutr Res Pract. 2012; 6(3):213-20. PMC: 3395786. DOI: 10.4162/nrp.2012.6.3.213. View

15.

Zhang Y, Gan R, Li S, Zhou Y, Li A, Xu D . Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases. Molecules. 2015; 20(12):21138-56. PMC: 6331972. DOI: 10.3390/molecules201219753. View

16.

Li P, Xu J, Shi Y, Ye Y, Chen K, Yang J . Association between zinc intake and risk of digestive tract cancers: a systematic review and meta-analysis. Clin Nutr. 2013; 33(3):415-20. DOI: 10.1016/j.clnu.2013.10.001. View

17.

Pakseresht M, Forman D, Malekzadeh R, Yazdanbod A, West R, Greenwood D . Dietary habits and gastric cancer risk in north-west Iran. Cancer Causes Control. 2011; 22(5):725-36. DOI: 10.1007/s10552-011-9744-5. View

18.

Jakszyn P, Agudo A, Lujan-Barroso L, Bueno-de-Mesquita H, Jenab M, Navarro C . Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study. Int J Cancer. 2011; 130(11):2654-63. DOI: 10.1002/ijc.26263. View

19.

LAUREN P . THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. Acta Pathol Microbiol Scand. 1965; 64:31-49. DOI: 10.1111/apm.1965.64.1.31. View

20.

Takachi R, Tsubono Y, Baba K, Inoue M, Sasazuki S, Iwasaki M . Red meat intake may increase the risk of colon cancer in Japanese, a population with relatively low red meat consumption. Asia Pac J Clin Nutr. 2011; 20(4):603-12. View