Epigenetic Modifications in the Accumulation and Function of Myeloid-derived Suppressor Cells

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Nov 28

PMID 36439186

Authors

Liangjie Xu

Cuicui Zhou

Yi Liang

Tinpan Fan

Fen Zhang

Xinxin Chen

Wei Yuan

Affiliations

Soon will be listed here.

Abstract

Myeloid-derived suppressor cells (MDSCs) are key players under various pathologic conditions, such as cancer. Epigenetic modifications such as DNA methylation, RNA-mediated processes, and histone modification can alter gene transcription, and thus regulating pathological process. Studies have shown that epigenetic modification contributes to the accumulation and function of MDSCs. This review summarizes the crosstalk between the epigenetic alterations and MDSCs functions, and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modification impact on the disease development, which represents as a promising therapeutic strategy for the related disorders.

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References

Lu Z, Zou J, Li S, Topper M, Tao Y, Zhang H . Epigenetic therapy inhibits metastases by disrupting premetastatic niches. Nature. 2020; 579(7798):284-290. PMC: 8765085. DOI: 10.1038/s41586-020-2054-x. View

Ni H, Zhang L, Huang H, Dai S, Li J . Connecting METTL3 and intratumoural CD33 MDSCs in predicting clinical outcome in cervical cancer. J Transl Med. 2020; 18(1):393. PMC: 7565373. DOI: 10.1186/s12967-020-02553-z. View

Sahakian E, Powers J, Chen J, Deng S, Cheng F, Distler A . Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function. Mol Immunol. 2014; 63(2):579-85. PMC: 4252813. DOI: 10.1016/j.molimm.2014.08.002. View

Lu C, Liu Z, Klement J, Yang D, Merting A, Poschel D . WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape. J Immunother Cancer. 2021; 9(7). PMC: 8323468. DOI: 10.1136/jitc-2021-002624. View

Wang Y, Schafer C, Hough K, Tousif S, Duncan S, Kearney J . Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5. J Immunol. 2018; 201(1):278-295. PMC: 6008229. DOI: 10.4049/jimmunol.1701069. View

Lin L, Hou J, Ma F, Wang P, Liu X, Li N . Type I IFN inhibits innate IL-10 production in macrophages through histone deacetylase 11 by downregulating microRNA-145. J Immunol. 2013; 191(7):3896-904. DOI: 10.4049/jimmunol.1203450. View

Jiang M, Chen J, Zhang W, Zhang R, Ye Y, Liu P . Interleukin-6 -Signaling Pathway Promotes Immunosuppressive Myeloid-Derived Suppressor Cells Suppression of Suppressor of Cytokine Signaling 3 in Breast Cancer. Front Immunol. 2018; 8:1840. PMC: 5736866. DOI: 10.3389/fimmu.2017.01840. View

Han X, Luan T, Sun Y, Yan W, Wang D, Zeng X . MicroRNA 449c Mediates the Generation of Monocytic Myeloid-Derived Suppressor Cells by Targeting STAT6. Mol Cells. 2020; 43(9):793-803. PMC: 7528684. DOI: 10.14348/molcells.2020.2307. View

Condamine T, Mastio J, Gabrilovich D . Transcriptional regulation of myeloid-derived suppressor cells. J Leukoc Biol. 2015; 98(6):913-22. PMC: 4661041. DOI: 10.1189/jlb.4RI0515-204R. View

10.

Shang C, Sun Y, Wang Y, Shi H, Han X, Mo Y . CXCL10 conditions alveolar macrophages within the premetastatic niche to promote metastasis. Cancer Lett. 2022; 537:215667. DOI: 10.1016/j.canlet.2022.215667. View

11.

Holtschke T, Lohler J, Kanno Y, Fehr T, Giese N, Rosenbauer F . Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell. 1996; 87(2):307-17. DOI: 10.1016/s0092-8674(00)81348-3. View

12.

Robertson K . DNA methylation and human disease. Nat Rev Genet. 2005; 6(8):597-610. DOI: 10.1038/nrg1655. View

13.

Hollen M, Stortz J, Darden D, Dirain M, Nacionales D, Hawkins R . Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis. Crit Care. 2019; 23(1):355. PMC: 6854728. DOI: 10.1186/s13054-019-2628-x. View

14.

Shang W, Gao Y, Tang Z, Zhang Y, Yang R . The Pseudogene Promotes the Suppressive Function and Differentiation of Monocytic MDSCs. Cancer Immunol Res. 2019; 7(5):813-827. DOI: 10.1158/2326-6066.CIR-18-0443. View

15.

Ji Q, Hu H, Yang F, Yuan J, Yang Y, Jiang L . CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression. J Cell Sci. 2014; 127(Pt 21):4679-91. DOI: 10.1242/jcs.154245. View

16.

Baghbani E, Noorolyai S, Duijf P, Silvestris N, Kolahian S, Hashemzadeh S . The impact of microRNAs on myeloid-derived suppressor cells in cancer. Hum Immunol. 2021; 82(9):668-678. DOI: 10.1016/j.humimm.2021.04.009. View

17.

Quan Z, He Y, Luo C, Xia Y, Zhao Y, Liu N . Interleukin 6 induces cell proliferation of clear cell renal cell carcinoma by suppressing hepaCAM via the STAT3-dependent up-regulation of DNMT1 or DNMT3b. Cell Signal. 2017; 32:48-58. DOI: 10.1016/j.cellsig.2017.01.017. View

18.

Schwartz S, Agarwala S, Mumbach M, Jovanovic M, Mertins P, Shishkin A . High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell. 2013; 155(6):1409-21. PMC: 3956118. DOI: 10.1016/j.cell.2013.10.047. View

19.

Geula S, Moshitch-Moshkovitz S, Dominissini D, AlFatah Mansour A, Kol N, Salmon-Divon M . Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation. Science. 2015; 347(6225):1002-6. DOI: 10.1126/science.1261417. View

20.

Xin J, Zhang Z, Su X, Wang L, Zhang Y, Yang R . Epigenetic Component p66a Modulates Myeloid-Derived Suppressor Cells by Modifying STAT3. J Immunol. 2017; 198(7):2712-2720. DOI: 10.4049/jimmunol.1601712. View