Hibiscus Sabdariffa (Roselle) Calyx: a Systematic and Meta-analytic Review of Memory-enhancing, Anti-neuroinflammatory and Antioxidative Activities

Overview

Journal Inflammopharmacology

Specialty Pharmacology

Date 2022 Nov 27

PMID 36436183

Authors

Tosin A Olasehinde

Temitope C Ekundayo

Kunle Okaiyeto

Ademola O Olaniran

Affiliations

Soon will be listed here.

Abstract

Background: In this study, we summarized the preclinical investigations of the neuroprotective activities of Hibiscus sabdariffa (HSD) extract via its effect on memory function, neuroinflammation and oxidative damage in the central nervous system, which may help to guide future studies.

Methods: Preclinical studies that investigated the effect of HSD extract on memory impairment, neuroinflammation and oxidative stress-induced neuronal damage were searched systematically in PubMed, EBSCOhost (including MEDLINE, CINAHL, APA PsycInfo, etc.), Web of Science (WoS) and Scopus. Parameters and indexes included Morris water maze, passive avoidance test, acetylcholinesterase activity, interleukin 1 (IL-1), tumour necrosis factor-alpha (TNF-α), MAPK, malondialdehyde (MDA), glutathione (GSH), reactive oxygen species (ROS) and mitochondria membrane potential (MMP).

Results: A total of 285 documents were identified; however, only ten articles were included and used for meta-analysis. The meta-analytic outcome revealed that HSD did not show any significant effect on memory function, neuroinflammatory biomarkers (IL-1, MAPK) and oxidative stress (GSH, MDA, ROS and MMP) in neuronal cells and tissues.

Conclusions: Individual study revealed that HSD showed improved memory function, attenuated neuroinflammation and prevented oxidative damage to neurons. However, a conflicting result was observed from the meta-analytic outcomes which showed that HSD has no significant effect on cognitive impairment, neuroinflammation and oxidative stress-induced neuronal damage. However the contradiction in this finding may be associated with small number of studies included. Hence, more studies on the memory-enhacing effects and anti-neuroinflammatory activity of HSD in preclinical and clinical model are required to validate its neuroprotective effect.

Citing Articles

Synergistic Antibacterial Proficiency of Green Bioformulated Zinc Oxide Nanoparticles with Potential Fosfomycin Synergism against Nosocomial Bacterial Pathogens.

Almaary K, Taha Yassin M, Elgorban A, Al-Otibi F, Al-Askar A, Maniah K Microorganisms. 2023; 11(3).

PMID: 36985218 PMC: 10053094. DOI: 10.3390/microorganisms11030645.

References

Aarsland D, Batzu L, Halliday G, Geurtsen G, Ballard C, Chaudhuri K . Author Correction: Parkinson disease-associated cognitive impairment. Nat Rev Dis Primers. 2021; 7(1):53. DOI: 10.1038/s41572-021-00292-z. View

Amos A, Khiatah B . Mechanisms of Action of Nutritionally Rich Therapeutic Uses in Major Common Chronic Diseases: A Literature Review. J Am Nutr Assoc. 2021; 41(1):116-124. DOI: 10.1080/07315724.2020.1848662. View

Balduzzi S, Rucker G, Schwarzer G . How to perform a meta-analysis with R: a practical tutorial. Evid Based Ment Health. 2019; 22(4):153-160. PMC: 10231495. DOI: 10.1136/ebmental-2019-300117. View

El Bayani G, Marpaung N, Simorangkir D, Sianipar I, Ibrahim N, Kartinah N . Anti-inflammatory Effects of Hibiscus Sabdariffa Linn. on the IL-1β/IL-1ra Ratio in Plasma and Hippocampus of Overtrained Rats and Correlation with Spatial Memory. Kobe J Med Sci. 2018; 64(2):E73-E83. PMC: 6347049. View

Chen Z, Huang J, Yang S, Hong F . Role of Cholinergic Signaling in Alzheimer's Disease. Molecules. 2022; 27(6). PMC: 8949236. DOI: 10.3390/molecules27061816. View

Da-Costa-Rocha I, Bonnlaender B, Sievers H, Pischel I, Heinrich M . Hibiscus sabdariffa L. - a phytochemical and pharmacological review. Food Chem. 2014; 165:424-43. DOI: 10.1016/j.foodchem.2014.05.002. View

DeTure M, Dickson D . The neuropathological diagnosis of Alzheimer's disease. Mol Neurodegener. 2019; 14(1):32. PMC: 6679484. DOI: 10.1186/s13024-019-0333-5. View

El-Shiekh R, Ashour R, Abd El-Haleim E, Ahmed K, Abdel-Sattar E . Hibiscus sabdariffa L.: A potent natural neuroprotective agent for the prevention of streptozotocin-induced Alzheimer's disease in mice. Biomed Pharmacother. 2020; 128:110303. DOI: 10.1016/j.biopha.2020.110303. View

Fakeye T, Pal A, Khanuja S . Anxiolytic and sedative effects of extracts of Hibiscus sabdariffa Linn (family Malvaceae). Afr J Med Med Sci. 2008; 37(1):49-54. View

10.

Fang Y, Doyle M, Chen J, Alosco M, Mez J, Satizabal C . Association between inflammatory biomarkers and cognitive aging. PLoS One. 2022; 17(9):e0274350. PMC: 9462682. DOI: 10.1371/journal.pone.0274350. View

11.

Gao H, Hong J . Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol. 2008; 29(8):357-65. PMC: 4794280. DOI: 10.1016/j.it.2008.05.002. View

12.

Haam J, Yakel J . Cholinergic modulation of the hippocampal region and memory function. J Neurochem. 2017; 142 Suppl 2:111-121. PMC: 5645066. DOI: 10.1111/jnc.14052. View

13.

Higgins J, Thompson S . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186. View

14.

Jabeur I, Pereira E, Barros L, Calhelha R, Sokovic M, Oliveira M . Hibiscus sabdariffa L. as a source of nutrients, bioactive compounds and colouring agents. Food Res Int. 2017; 100(Pt 1):717-723. DOI: 10.1016/j.foodres.2017.07.073. View

15.

Knapp G, Hartung J . Improved tests for a random effects meta-regression with a single covariate. Stat Med. 2003; 22(17):2693-710. DOI: 10.1002/sim.1482. View

16.

Koch K, Weldle N, Baier S, Buchter C, Watjen W . Hibiscus sabdariffa L. extract prolongs lifespan and protects against amyloid-β toxicity in Caenorhabditis elegans: involvement of the FoxO and Nrf2 orthologues DAF-16 and SKN-1. Eur J Nutr. 2019; 59(1):137-150. DOI: 10.1007/s00394-019-01894-w. View

17.

Kwon H, Koh S . Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener. 2020; 9(1):42. PMC: 7689983. DOI: 10.1186/s40035-020-00221-2. View

18.

Lardenoije R, Iatrou A, Kenis G, Kompotis K, Steinbusch H, Mastroeni D . The epigenetics of aging and neurodegeneration. Prog Neurobiol. 2015; 131:21-64. PMC: 6477921. DOI: 10.1016/j.pneurobio.2015.05.002. View

19.

Lopez-Romero D, Izquierdo-Vega J, Morales-Gonzalez J, Madrigal-Bujaidar E, Chamorro-Cevallos G, Sanchez-Gutierrez M . Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin. Nutrients. 2018; 10(12). PMC: 6316078. DOI: 10.3390/nu10121954. View

20.

Lorenzana-Martinez G, Santerre A, Andrade-Gonzalez I, Banuelos-Pineda J . Effects of calyces on spatial memory and hippocampal expression of BDNF in ovariectomized rats. Nutr Neurosci. 2020; 25(4):670-680. DOI: 10.1080/1028415X.2020.1804095. View