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Exclusive Breastfeeding and Childhood Morbidity: A Narrative Review

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Publisher MDPI
Date 2022 Nov 26
PMID 36429518
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Abstract

Globally, diarrheal diseases and acute respiratory infections are the leading causes of morbidity and mortality in children under 5 years old. The benefits of exclusive breastfeeding in reducing the risk of gastrointestinal and respiratory infections are well documented. Optimal breastfeeding may potentially save the lives of about 800,000 children in low-income settings. Despite the evidence, around 63% of infants from birth to 6 months are not exclusively breastfed worldwide. We searched the literature published between 2010 and 2022 in Medline, Embase, and Scopus on the association between exclusive breastfeeding and infectious diseases. We selected and reviewed 70 relevant studies. Our findings expand and confirm the positive association between exclusive breastfeeding and reduced risk of a number of gastrointestinal, respiratory, and other infections in 60 out of 70 studies observed in both low- and high-income settings. Several studies analyzing exclusive breastfeeding duration reported that a longer exclusive breastfeeding duration is protective against many infectious diseases. This review also reported a lack of standardized definition for measuring exclusive breastfeeding in many studies. Overall, the results highlight the benefits of exclusive breastfeeding in many studies and suggests reporting exclusive breastfeeding in future studies using a consistent definition to enable better monitoring of exclusive breastfeeding rates.

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References
1.
Mihrshahi S, Ara G, Khanam M, Rasheed S, Agho K, Kabir A . The Shishu Pushti Trial-Extended Peer Counseling for Improving Feeding Practices and Reducing Undernutrition in Children Aged 0-48 Months in Urban Bangladesh: Protocol for a Cluster-Randomized Controlled Trial. JMIR Res Protoc. 2022; 11(2):e31475. PMC: 8861872. DOI: 10.2196/31475. View

2.
do Nascimento R, Baptista P, Lopes K, Pimentel A, Cruz F, Ximenes R . Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness. J Pediatr (Rio J). 2021; 97(5):500-507. PMC: 9432170. DOI: 10.1016/j.jped.2020.10.018. View

3.
Payne S, Quigley M . Breastfeeding and infant hospitalisation: analysis of the UK 2010 Infant Feeding Survey. Matern Child Nutr. 2016; 13(1). PMC: 6865925. DOI: 10.1111/mcn.12263. View

4.
Christensen N, Bruun S, Sondergaard J, Christesen H, Fisker N, Zachariassen G . Breastfeeding and Infections in Early Childhood: A Cohort Study. Pediatrics. 2020; 146(5). DOI: 10.1542/peds.2019-1892. View

5.
Amour C, Gratz J, Mduma E, Svensen E, Rogawski E, McGrath M . Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study. Clin Infect Dis. 2016; 63(9):1171-1179. PMC: 5064165. DOI: 10.1093/cid/ciw542. View