The Lipid Profile and Biochemical Parameters of COPD Patients in Relation to Smoking Status

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2022 Nov 26

PMID 36428504

Authors

Cristina Vicol

Ioana Buculei

Oana Elena Melinte

Mona Elisabeta Dobrin

Emanuel Ioan Stavarache

Cristina-Maria Gavrilescu

Paraschiva Postolache

Daniela Matei

Antigona Trofor

Affiliations

Soon will be listed here.

Abstract

Tobacco consumption is the most incriminated and studied risk factor for Chronic obstructive pulmonary disease (COPD), but other factors such as air pollution, are also linked to this disease. One of the known aspects of this chronic lung disease is that its occurrence is mainly due to the chronic inflammation of the airways. Lipid metabolism seems to be affected by smoking, with studies showing a correlation between this habit and high levels of triglycerides and low levels of high-density lipoprotein cholesterol (HDL-CHOL). Uric acid concentration is thought to reflect the antioxidative capacity of the body because it is the most abundant aqueous antioxidant. The aim of this study was to investigate the lipid profile and biochemical parameters of COPD patients in relation to smoking status. The present study was conducted between 2020 and 2021 in the Clinical Hospital of Pneumology in Iasi, Romania. Patients diagnosed with COPD (n = 52) were included and divided in three groups depending on their smoking status: non-smokers, smokers and ex-smokers. The obtained results show low correlations between COPD stages and serum uric acid concentrations (r = 0.4; ˂ 0.05), smoking status (smoker/non-smoker/ex-smoker) and total serum cholesterol values (r = 0.45; ˂ 0.05), but also between serum urea concentrations and the number of packs-years for the smoker/ex-smoker groups (r = 0.45, ˂ 0.05). Smoking was associated with changes in the lipid profile of smokers and ex-smokers, along with increased low-density lipoprotein cholesterol (LDL-CHOL) and low serum uric acid values.

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References

Sliwinska-Mosson M, Mihulka E, Milnerowicz H . [Assessment of lipid profile in non-smoking and smoking young health persons]. Przegl Lek. 2015; 71(11):585-7. View

Frati A, Iniestra F, Ariza C . Acute effect of cigarette smoking on glucose tolerance and other cardiovascular risk factors. Diabetes Care. 1996; 19(2):112-8. DOI: 10.2337/diacare.19.2.112. View

Lee S, Seo J, Kim S, Jeong J, Nam B, Lee J . The changes of blood glucose control and lipid profiles after short-term smoking cessation in healthy males. Psychiatry Investig. 2011; 8(2):149-54. PMC: 3149110. DOI: 10.4306/pi.2011.8.2.149. View

Esteve E, Ricart W, Fernandez-Real J . Dyslipidemia and inflammation: an evolutionary conserved mechanism. Clin Nutr. 2005; 24(1):16-31. DOI: 10.1016/j.clnu.2004.08.004. View

Vujic T, Nagorni O, Maric G, Popovic L, Jankovic J . Metabolic syndrome in patients with chronic obstructive pulmonary disease: frequency and relationship with systemic inflammation. Hippokratia. 2017; 20(2):110-114. PMC: 5388510. View

Pozzi R, De Berardis B, Paoletti L, Guastadisegni C . Inflammatory mediators induced by coarse (PM2.5-10) and fine (PM2.5) urban air particles in RAW 264.7 cells. Toxicology. 2002; 183(1-3):243-54. DOI: 10.1016/s0300-483x(02)00545-0. View

Hanna B, Hamed J, Touhala L . Serum uric Acid in smokers. Oman Med J. 2012; 23(4):269-74. PMC: 3273920. View

Szkup M, Jurczak A, Karakiewicz B, Kotwas A, Kopec J, Grochans E . Influence of cigarette smoking on hormone and lipid metabolism in women in late reproductive stage. Clin Interv Aging. 2018; 13:109-115. PMC: 5775744. DOI: 10.2147/CIA.S140487. View

Ames B, Cathcart R, Schwiers E, Hochstein P . Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A. 1981; 78(11):6858-62. PMC: 349151. DOI: 10.1073/pnas.78.11.6858. View

10.

Haj Mouhamed D, Ezzaher A, Neffati F, Douki W, Gaha L, Najjar M . Effect of cigarette smoking on plasma uric acid concentrations. Environ Health Prev Med. 2011; 16(5):307-12. PMC: 3156839. DOI: 10.1007/s12199-010-0198-2. View

11.

Orth S, Ritz E . The renal risks of smoking: an update. Curr Opin Nephrol Hypertens. 2002; 11(5):483-8. DOI: 10.1097/00041552-200209000-00002. View

12.

BORNEMISZA P, Suciu I . Effect of cigarette smoking on the blood glucose level in normals and diabetics. Med Interne. 1980; 18(4):353-6. View

13.

Cao W, Medvedev A, Daniel K, Collins S . beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase. J Biol Chem. 2001; 276(29):27077-82. DOI: 10.1074/jbc.M101049200. View

14.

Yang B, Bloom M, Markevych I, Qian Z, Vaughn M, Cummings-Vaughn L . Exposure to ambient air pollution and blood lipids in adults: The 33 Communities Chinese Health Study. Environ Int. 2018; 119:485-492. DOI: 10.1016/j.envint.2018.07.016. View

15.

Chimura Y, Daimon T, Wakabayashi I . Proneness to high blood lipid-related indices in female smokers. Lipids Health Dis. 2019; 18(1):113. PMC: 6515650. DOI: 10.1186/s12944-019-1050-3. View

16.

Kim K, Ha B, Seog W, Hwang I . Long-term exposure to air pollution and the blood lipid levels of healthy young men. Environ Int. 2022; 161:107119. DOI: 10.1016/j.envint.2022.107119. View

17.

Slatore C, Bryson C, Au D . The association of inhaled corticosteroid use with serum glucose concentration in a large cohort. Am J Med. 2009; 122(5):472-8. DOI: 10.1016/j.amjmed.2008.09.048. View

18.

Lam K, Jordan R, Jiang C, Thomas G, Miller M, Zhang W . Airflow obstruction and metabolic syndrome: the Guangzhou Biobank Cohort Study. Eur Respir J. 2009; 35(2):317-23. DOI: 10.1183/09031936.00024709. View

19.

Li X, Zhao Y, Huang L, Xu H, Liu X, Yang J . Effects of smoking and alcohol consumption on lipid profile in male adults in northwest rural China. Public Health. 2018; 157:7-13. DOI: 10.1016/j.puhe.2018.01.003. View

20.

Park S, Larson J . The relationship between physical activity and metabolic syndrome in people with chronic obstructive pulmonary disease. J Cardiovasc Nurs. 2013; 29(6):499-507. PMC: 4032377. DOI: 10.1097/JCN.0000000000000096. View