Ganaxolone: A New Treatment for CDKL5 Deficiency Disorder

Overview

Journal Epilepsy Curr

Publisher Sage Publications

Date 2022 Nov 25

PMID 36426195

Authors

David G Vossler

Affiliations

Soon will be listed here.

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References

Sperling M, Klein P, Tsai J . Randomized, double-blind, placebo-controlled phase 2 study of ganaxolone as add-on therapy in adults with uncontrolled partial-onset seizures. Epilepsia. 2017; 58(4):558-564. DOI: 10.1111/epi.13705. View

Leonard H, Junaid M, Wong K, Aimetti A, Knight E, Downs J . Influences on the trajectory and subsequent outcomes in CDKL5 deficiency disorder. Epilepsia. 2021; 63(2):352-363. DOI: 10.1111/epi.17125. View

Amin S, Monaghan M, Aledo-Serrano A, Bahi-Buisson N, Chin R, Clarke A . International Consensus Recommendations for the Assessment and Management of Individuals With CDKL5 Deficiency Disorder. Front Neurol. 2022; 13:874695. PMC: 9251467. DOI: 10.3389/fneur.2022.874695. View

Vaitkevicius H, Ramsay R, Swisher C, Husain A, Aimetti A, Gasior M . Intravenous ganaxolone for the treatment of refractory status epilepticus: Results from an open-label, dose-finding, phase 2 trial. Epilepsia. 2022; 63(9):2381-2391. PMC: 9796093. DOI: 10.1111/epi.17343. View

Zuberi S, Wirrell E, Yozawitz E, Wilmshurst J, Specchio N, Riney K . ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022; 63(6):1349-1397. DOI: 10.1111/epi.17239. View