Visualizing Diastolic Failure: Non-invasive Imaging-biomarkers in Patients with Heart Failure with Preserved Ejection Fraction

Overview

Journal EBioMedicine

Specialty Biomedical Engineering

Date 2022 Nov 24

PMID 36423377

Authors

Alexander Schulz

Andreas Schuster

Affiliations

Soon will be listed here.

Abstract

Heart failure with preserved ejection fraction is an increasing challenge for modern day medicine and has been drawing more attention recently. Invasive right heart catheterization represents the mainstay for the diagnosis of diastolic dysfunction, however due to its attributable risk of an invasive procedure, other non-invasive clinical pathways are trying to approach this pathology in clinical practice. Diastolic failure is complex, and imaging is based on various parameters. In addition to transthoracic echocardiography, numerous novel imaging approaches, such as cardiac magnetic resonance imaging, computed tomography, positron emission (computed) tomography or single photon emission computed tomography techniques are being used to supplement deeper insights into causal pathology and might open targets for dedicated therapy options. This article provides insights into these sophisticated imaging techniques, their incremental value for the diagnosis of this poorly understood disease and recent promising results for an enhanced prognostication of outcome and therapy monitoring.

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