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The Immediate and Long-term Effects of Prenatal Opioid Exposure

Overview
Journal Front Pediatr
Specialty Pediatrics
Date 2022 Nov 24
PMID 36419918
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Abstract

The opioid epidemic has adversely affected neonates and children, yet the mechanisms by which it impacts this population are not well understood. Not only does prenatal opioid exposure result in short-term consequences shortly after birth, it also creates long-term sequelae that may predispose these children to physical, emotional, psychiatric, cognitive, and socioeconomic problems in the future. This article provides a scoping overview of the long-term effects of antenatal opioid exposure on neonates and children as well as quality improvement and research efforts to understand and mitigate this major public health concern.

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References
1.
Lembeck A, Tuttle D, Locke R, Lawler L, Jimenez P, Mackley A . Breastfeeding and Formula Selection in Neonatal Abstinence Syndrome. Am J Perinatol. 2020; 38(14):1488-1493. DOI: 10.1055/s-0040-1713754. View

2.
Short V, Gannon M, Abatemarco D . The Association Between Breastfeeding and Length of Hospital Stay Among Infants Diagnosed with Neonatal Abstinence Syndrome: A Population-Based Study of In-Hospital Births. Breastfeed Med. 2016; 11:343-9. DOI: 10.1089/bfm.2016.0084. View

3.
Wouldes T, Woodward L . Neurobehavior of newborn infants exposed prenatally to methadone and identification of a neurobehavioral profile linked to poorer neurodevelopmental outcomes at age 24 months. PLoS One. 2020; 15(10):e0240905. PMC: 7567379. DOI: 10.1371/journal.pone.0240905. View

4.
Loudin S, Haas J, Payne M, Linz M, Meaney-Delman D, Honein M . Identifying Co-Exposure to Opiates and Gabapentin During Pregnancy. J Pediatr. 2019; 217:196-198. PMC: 7503060. DOI: 10.1016/j.jpeds.2019.09.029. View

5.
Dryden C, Young D, Hepburn M, Mactier H . Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources. BJOG. 2009; 116(5):665-71. DOI: 10.1111/j.1471-0528.2008.02073.x. View