The Immediate and Long-term Effects of Prenatal Opioid Exposure
Overview
Authors
Affiliations
The opioid epidemic has adversely affected neonates and children, yet the mechanisms by which it impacts this population are not well understood. Not only does prenatal opioid exposure result in short-term consequences shortly after birth, it also creates long-term sequelae that may predispose these children to physical, emotional, psychiatric, cognitive, and socioeconomic problems in the future. This article provides a scoping overview of the long-term effects of antenatal opioid exposure on neonates and children as well as quality improvement and research efforts to understand and mitigate this major public health concern.
Shah D, Adelli R, Chroust A, Lewis N, Olsen M J Perinatol. 2025; .
PMID: 39929991 DOI: 10.1038/s41372-025-02211-6.
Nyberg H, Bogen I, Nygaard E, Achterberg M, Andersen J Psychopharmacology (Berl). 2024; 242(3):663-680.
PMID: 39633163 PMC: 11861248. DOI: 10.1007/s00213-024-06718-2.
Prenatal Opioid Exposure and Immune-Related Conditions in Children.
Kelty E, Rae K, Jantzie L, Wyrwoll C, Preen D JAMA Netw Open. 2024; 7(1):e2351933.
PMID: 38231512 PMC: 10794935. DOI: 10.1001/jamanetworkopen.2023.51933.
Yun H, Nagaraj U, Grant P, Merhar S, Ou X, Lin W AJNR Am J Neuroradiol. 2024; 45(2):218-223.
PMID: 38216298 PMC: 11285994. DOI: 10.3174/ajnr.A8101.
Neonatal Abstinence Syndrome: An Insight Over Impact of Maternal Substance Use.
Dumbhare O, Taksande A Cureus. 2023; 15(10):e47980.
PMID: 38034154 PMC: 10686242. DOI: 10.7759/cureus.47980.