Non-alcoholic Fatty Liver Disease Across Endocrinopathies: Interaction with Sex Hormones

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2022 Nov 24

PMID 36419770

Authors

Sara Arefhosseini

Mehrangiz Ebrahimi-Mameghani

Farzad Najafipour

Helda Tutunchi

Affiliations

Soon will be listed here.

Abstract

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most frequent chronic liver disease globally. NAFLD is strongly associated with metabolic syndrome and it has been recently suggested that to rename NAFLD as metabolic dysfunction-associated fatty liver disease (MAFLD). NAFLD has been studied in different endocrine axes and accumulating body of clinical and experimental studies have suggested that NAFLD is associated with polycystic ovarian syndrome (PCOS), hypopituitarism, growth hormone deficiency (GHD), hypogonadism and other endocrine disorders. In fact, endocrine dysfunction may be considered as the major contributor for the development, progression, and severity of NAFLD. In the present comprehensive review, we discussed the epidemiological and clinical evidence on the epidemiology, pathophysiology, and management of NAFLD in endocrine disorders, with an emphasis on the effects of sex-specific hormones/conditions as well as molecular basis of NAFLD development in these endocrine diseases.

Citing Articles

Copper status and its relation to abdominal obesity indices and liver function in non-alcoholic fatty liver disease: a case-control study.

Arefhosseini S, Tutunchi H, Arefhosseini S, Ghavami S, Ebrahimi-Mameghani M BMC Res Notes. 2024; 17(1):370.

PMID: 39702499 PMC: 11660630. DOI: 10.1186/s13104-024-07025-x.

The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD.

Aghajani T, Arefhosseini S, Ebrahimi-Mameghani M, Safaralizadeh R Food Sci Nutr. 2024; 12(10):7177-7185.

PMID: 39479697 PMC: 11521746. DOI: 10.1002/fsn3.4267.

A Dose-Response Study on the Relationship between White Meat Intake and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Southern Italy: Results from the Nutrihep Study.

Guido D, Cerabino N, Di Chito M, Donghia R, Randazzo C, Bonfiglio C Nutrients. 2024; 16(18).

PMID: 39339694 PMC: 11435003. DOI: 10.3390/nu16183094.

Associations between metabolic dysfunction-associated fatty liver disease, chronic kidney disease, and abdominal obesity: a national retrospective cohort study.

Cen C, Fan Z, Ding X, Tu X, Liu Y Sci Rep. 2024; 14(1):12645.

PMID: 38825630 PMC: 11144701. DOI: 10.1038/s41598-024-63386-0.

Hypogonadism and nonalcoholic fatty liver disease.

Papadimitriou K, Mousiolis A, Mintziori G, Tarenidou C, Polyzos S, Goulis D Endocrine. 2024; 86(1):28-47.

PMID: 38771482 DOI: 10.1007/s12020-024-03878-1.

References

Xu L, Xu C, Yu C, Miao M, Zhang X, Zhu Z . Association between serum growth hormone levels and nonalcoholic fatty liver disease: a cross-sectional study. PLoS One. 2012; 7(8):e44136. PMC: 3432067. DOI: 10.1371/journal.pone.0044136. View

Bruno S, Maisonneuve P, Castellana P, Rotmensz N, Rossi S, Maggioni M . Incidence and risk factors for non-alcoholic steatohepatitis: prospective study of 5408 women enrolled in Italian tamoxifen chemoprevention trial. BMJ. 2005; 330(7497):932. PMC: 556336. DOI: 10.1136/bmj.38391.663287.E0. View

Chen Z, Zhao H, He L, Shi Y, Qin Y, Shi Y . Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet. 2010; 43(1):55-9. DOI: 10.1038/ng.732. View

Kupelian V, Page S, Araujo A, Travison T, Bremner W, McKinlay J . Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab. 2006; 91(3):843-50. DOI: 10.1210/jc.2005-1326. View

Koga M, Saito H, Mukai M, Saibara T, Kasayama S . Serum dehydroepiandrosterone sulphate levels in patients with non-alcoholic fatty liver disease. Intern Med. 2011; 50(16):1657-61. DOI: 10.2169/internalmedicine.50.4682. View

Lazo M, Zeb I, Nasir K, Tracy R, Budoff M, Ouyang P . Association Between Endogenous Sex Hormones and Liver Fat in a Multiethnic Study of Atherosclerosis. Clin Gastroenterol Hepatol. 2015; 13(9):1686-93.e2. PMC: 4500744. DOI: 10.1016/j.cgh.2014.12.033. View

Grossmann M, Wierman M, Angus P, Handelsman D . Reproductive Endocrinology of Nonalcoholic Fatty Liver Disease. Endocr Rev. 2018; 40(2):417-446. DOI: 10.1210/er.2018-00158. View

Lindheim L, Bashir M, Munzker J, Trummer C, Zachhuber V, Leber B . Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study. PLoS One. 2017; 12(1):e0168390. PMC: 5207627. DOI: 10.1371/journal.pone.0168390. View

Won Y, Seo S, Yun B, Cho S, Choi Y, Lee B . Non-alcoholic fatty liver disease in polycystic ovary syndrome women. Sci Rep. 2021; 11(1):7085. PMC: 8007604. DOI: 10.1038/s41598-021-86697-y. View

10.

McKenzie J, Fisher B, Jaap A, Stanley A, Paterson K, Sattar N . Effects of HRT on liver enzyme levels in women with type 2 diabetes: a randomized placebo-controlled trial. Clin Endocrinol (Oxf). 2006; 65(1):40-4. DOI: 10.1111/j.1365-2265.2006.02543.x. View

11.

Gilliland T, Dufour S, Shulman G, Petersen K, Emre S . Resolution of non-alcoholic steatohepatitis after growth hormone replacement in a pediatric liver transplant patient with panhypopituitarism. Pediatr Transplant. 2016; 20(8):1157-1163. DOI: 10.1111/petr.12819. View

12.

Carvalho A, Guerra-Junior G, Baptista M, Marques-de-Faria A, de Lemos-Marini S, Maciel-Guerra A . Turner syndrome: a pediatric diagnosis frequently made by non-pediatricians. J Pediatr (Rio J). 2010; 86(2):121-5. DOI: 10.2223/JPED.1985. View

13.

Sarkar M, Terrault N, Chan W, Cedars M, Huddleston H, Duwaerts C . Polycystic ovary syndrome (PCOS) is associated with NASH severity and advanced fibrosis. Liver Int. 2019; 40(2):355-359. PMC: 6980925. DOI: 10.1111/liv.14279. View

14.

Marino L, Jornayvaz F . Endocrine causes of nonalcoholic fatty liver disease. World J Gastroenterol. 2015; 21(39):11053-76. PMC: 4607905. DOI: 10.3748/wjg.v21.i39.11053. View

15.

Fan Y, Fang X, Tajima A, Geng X, Ranganathan S, Dong H . Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout mice. Front Endocrinol (Lausanne). 2015; 5:218. PMC: 4270248. DOI: 10.3389/fendo.2014.00218. View

16.

Liu S, Lazo M, Koteish A, Kao W, Shih M, Bonekamp S . Oral contraceptive pill use is associated with reduced odds of nonalcoholic fatty liver disease in menstruating women: results from NHANES III. J Gastroenterol. 2012; 48(10):1151-9. PMC: 4170913. DOI: 10.1007/s00535-012-0715-8. View

17.

Spremovic Radenovic S, Pupovac M, Andjic M, Bila J, Sreckovic S, Gudovic A . Prevalence, Risk Factors, and Pathophysiology of Nonalcoholic Fatty Liver Disease (NAFLD) in Women with Polycystic Ovary Syndrome (PCOS). Biomedicines. 2022; 10(1). PMC: 8773533. DOI: 10.3390/biomedicines10010131. View

18.

Dongiovanni P, Donati B, Fares R, Lombardi R, Mancina R, Romeo S . PNPLA3 I148M polymorphism and progressive liver disease. World J Gastroenterol. 2013; 19(41):6969-78. PMC: 3819533. DOI: 10.3748/wjg.v19.i41.6969. View

19.

Tutunchi H, Saghafi-Asl M, Asghari-Jafarabadi M, Ostadrahimi A . The relationship between severity of liver steatosis and metabolic parameters in a sample of Iranian adults. BMC Res Notes. 2020; 13(1):218. PMC: 7164143. DOI: 10.1186/s13104-020-05059-5. View

20.

Klein K, Rosenfield R, Santen R, Gawlik A, Backeljauw P, Gravholt C . Estrogen Replacement in Turner Syndrome: Literature Review and Practical Considerations. J Clin Endocrinol Metab. 2018; 103(5):1790-1803. DOI: 10.1210/jc.2017-02183. View