Factors Associated with Infant Mortality Due to Congenital Anomalies: A Population-Based Case-Control Study

Overview

Journal Iran J Public Health

Date 2022 Nov 21

PMID 36407744

Authors

Fatemeh Zolfizadeh

Maryam Ghorbani

Maryam Soltani

Shahab Rezaeian

Abdolhalim Rajabi

Koorosh Etemad

Mahmoud Hajipour

Ali Ghasemi

Halimeh Yaghoobi

Affiliations

Soon will be listed here.

Abstract

Background: Congenital anomalies are one of the major public health problems and one of the leading cause of infant mortality and morbidity. We aimed to investigate some factors associated with infant mortality due to congenital anomalies in several provinces of Iran.

Methods: This case-control study was conducted on 2199 women referring health centers of nine provinces of Iran 2015-2018. Cases were defined as mothers with infant death due to congenital anomalies, and control group comprised of mothers with live birth or infant deaths due to other causes (n=1986). The descriptive data were expressed as percentage and frequency. Factors associated with infant death due to congenital anomalies were evaluated and analyzed at 95% confidence level by logistic regression analysis.

Results: The multiple logistic regression analysis reveal that history of cesarean delivery [OR:2.13 ;95%CI (1.58-2.87)], maternal age [OR:1.94 ;95%CI (1.31-2.86)])], area of living [OR: 1.69;95%CI (1.22-2.33)], maternal smoking during pregnancy [OR: 1.41; 95%CI (1.02-1.95)], consanguineous marriage [OR:1.53;95%CI (1.12-2.08)], also low birth weight [OR: 3.09; 95%CI (2.23-4.30)] were significantly associated with infant death due to congenital anomalies.

Conclusion: Identification of factors associated with congenital anomalies has been shown to reduce treatment costs and medical complications of neonates. Therefore, genetic counseling and educational programs for high-risk women, and prenatal screening are essential to identify and prevent factors contributing to congenital abnormalities.

References

Singh G, Yu S . Infant Mortality in the United States, 1915-2017: Large Social Inequalities have Persisted for Over a Century. Int J MCH AIDS. 2019; 8(1):19-31. PMC: 6487507. DOI: 10.21106/ijma.271. View

Fredell L, Kockum I, Hansson E, Holmner S, Lundquist L, Lackgren G . Heredity of hypospadias and the significance of low birth weight. J Urol. 2002; 167(3):1423-7. View

Dastgiri S, Sheikhzadeh Y, Dastgiri A . Monitoring of congenital anomalies in developing countries: a pilot model in Iran. Stud Health Technol Inform. 2011; 164:157-61. View

Ebela I, Zile I, Zakis A, Folkmanis V, Rumba-Rozenfelde I . Mortality of children under five and prevalence of newborn congenital anomalies in relation to macroeconomic and socioeconomic factors in Latvia. Medicina (Kaunas). 2012; 47(12):667-74. View

Mashhadi Abdolahi H, Kargar Maher M, Afsharnia F, Dastgiri S . Prevalence of congenital anomalies: a community-based study in the northwest of iran. ISRN Pediatr. 2014; 2014:920940. PMC: 4005020. DOI: 10.1155/2014/920940. View

Morales-Suarez-Varela M, Bille C, Christensen K, Olsen J . Smoking habits, nicotine use, and congenital malformations. Obstet Gynecol. 2006; 107(1):51-7. DOI: 10.1097/01.AOG.0000194079.66834.d5. View

Nhoncanse G, Germano C, de Avo L, Melo D . Maternal and perinatal aspects of birth defects: a case-control study. Rev Paul Pediatr. 2014; 32(1):24-31. PMC: 4183001. DOI: 10.1590/s0103-05822014000100005. View

Roncancio C, Misnaza S, Pena I, Prieto F, Cannon M, Valencia D . Trends and characteristics of fetal and neonatal mortality due to congenital anomalies, Colombia 1999-2008. J Matern Fetal Neonatal Med. 2017; 31(13):1748-1755. PMC: 5741518. DOI: 10.1080/14767058.2017.1326901. View

Costa C, Gama S, Leal M . Congenital malformations in Rio de Janeiro, Brazil: prevalence and associated factors. Cad Saude Publica. 2006; 22(11):2423-31. DOI: 10.1590/s0102-311x2006001100016. View

10.

Bhide P, Kar A . A national estimate of the birth prevalence of congenital anomalies in India: systematic review and meta-analysis. BMC Pediatr. 2018; 18(1):175. PMC: 5970488. DOI: 10.1186/s12887-018-1149-0. View

11.

Mashuda F, Zuechner A, Chalya P, Kidenya B, Manyama M . Pattern and factors associated with congenital anomalies among young infants admitted at Bugando medical centre, Mwanza, Tanzania. BMC Res Notes. 2014; 7:195. PMC: 3974194. DOI: 10.1186/1756-0500-7-195. View

12.

Luz G, de Menezes Karam S, Dumith S . Congenital anomalies in Rio Grande do Sul State: a time series analysis. Rev Bras Epidemiol. 2019; 22:e190040. DOI: 10.1590/1980-549720190040. View

13.

Cui H, He C, Kang L, Li Q, Miao L, Shen L . Under-5-Years Child Mortality Due to Congenital Anomalies: A Retrospective Study in Urban and Rural China in 1996-2013. Am J Prev Med. 2016; 50(5):663-671. DOI: 10.1016/j.amepre.2015.12.013. View

14.

Louis B, Steven B, Margret N, Ronald N, Emmanuel L, Tadeo N . Prevalence and Factors Associated with Low Birth Weight among Teenage Mothers in New Mulago Hospital: A Cross Sectional Study. J Health Sci (El Monte). 2018; 4:192-199. PMC: 5775522. DOI: 10.17265/2328-7136/2016.04.003. View