Advances in the Study of Nicotinamide Adenine Dinucleotide Phosphate Oxidase in Myocardial Remodeling

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2022 Nov 21

PMID 36407440

Authors

Runran Miao

Libo Wang

Zhigang Chen

Shiqi Ge

Li Li

Kai Zhang

Yingen Chen

Wenjing Guo

Xulei Duan

Mingyang Zhu

Guoan Zhao

Fei Lin

Affiliations

Soon will be listed here.

Abstract

Myocardial remodeling is a key pathophysiological basis of heart failure, which seriously threatens human health and causes a severe economic burden worldwide. During chronic stress, the heart undergoes myocardial remodeling, mainly manifested by cardiomyocyte hypertrophy, apoptosis, interstitial fibrosis, chamber enlargement, and cardiac dysfunction. The NADPH oxidase family (NOXs) are multisubunit transmembrane enzyme complexes involved in the generation of redox signals. Studies have shown that NOXs are highly expressed in the heart and are involved in the pathological development process of myocardial remodeling, which influences the development of heart failure. This review summarizes the progress of research on the pathophysiological processes related to the regulation of myocardial remodeling by NOXs, suggesting that NOXs-dependent regulatory mechanisms of myocardial remodeling are promising new therapeutic targets for the treatment of heart failure.

Citing Articles

SERCA2a dysfunction in the pathophysiology of heart failure with preserved ejection fraction: a direct role is yet to be established.

Shooshtarian A, OGallagher K, Shah A, Zhang M Heart Fail Rev. 2025; .

PMID: 39843817 DOI: 10.1007/s10741-025-10487-1.

Identification of CAPG as a potential prognostic biomarker associated with immune cell infiltration and ferroptosis in uterine corpus endometrial carcinoma.

Liu J, Zhu W, Xia L, Zhu Q, Mao Y, Shen Y Front Endocrinol (Lausanne). 2024; 15:1452219.

PMID: 39600941 PMC: 11588481. DOI: 10.3389/fendo.2024.1452219.

Advancements in Cancer Therapy: Mycoviruses and Their Oncolytic Potential.

Kamala K, Ganapathy D, Sivaperumal P Cell Biochem Biophys. 2024; .

PMID: 39535660 DOI: 10.1007/s12013-024-01608-y.

Knockdown of ANGPTL2 promotes left ventricular systolic dysfunction by upregulation of NOX4 in mice.

Labbe P, Martel C, Shi Y, Montezano A, He Y, Gillis M Front Physiol. 2024; 15:1320065.

PMID: 38426206 PMC: 10902461. DOI: 10.3389/fphys.2024.1320065.

A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products.

Melotti L, Venerando A, Zivelonghi G, Carolo A, Marzorati S, Martinelli G Antioxidants (Basel). 2023; 12(9).

PMID: 37760033 PMC: 10526080. DOI: 10.3390/antiox12091730.

References

Gibb A, Hill B . Metabolic Coordination of Physiological and Pathological Cardiac Remodeling. Circ Res. 2018; 123(1):107-128. PMC: 6023588. DOI: 10.1161/CIRCRESAHA.118.312017. View

Sindona C, Schepici G, Contestabile V, Bramanti P, Mazzon E . NOX2 Activation in COVID-19: Possible Implications for Neurodegenerative Diseases. Medicina (Kaunas). 2021; 57(6). PMC: 8230853. DOI: 10.3390/medicina57060604. View

Mongue-Din H, Patel A, Looi Y, Grieve D, Anilkumar N, Sirker A . NADPH Oxidase-4 Driven Cardiac Macrophage Polarization Protects Against Myocardial Infarction-Induced Remodeling. JACC Basic Transl Sci. 2018; 2(6):688-698. PMC: 5803556. DOI: 10.1016/j.jacbts.2017.06.006. View

Matsushima S, Kuroda J, Zhai P, Liu T, Ikeda S, Nagarajan N . Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J Clin Invest. 2016; 126(9):3403-16. PMC: 5004961. DOI: 10.1172/JCI85624. View

Doughan A, Harrison D, Dikalov S . Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Circ Res. 2007; 102(4):488-96. DOI: 10.1161/CIRCRESAHA.107.162800. View

Ago T, Kuroda J, Pain J, Fu C, Li H, Sadoshima J . Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res. 2010; 106(7):1253-64. PMC: 2855780. DOI: 10.1161/CIRCRESAHA.109.213116. View

Gimenez M, Schickling B, Lopes L, Miller Jr F . Nox1 in cardiovascular diseases: regulation and pathophysiology. Clin Sci (Lond). 2015; 130(3):151-65. DOI: 10.1042/CS20150404. View

Zhang M, Shah A . ROS signalling between endothelial cells and cardiac cells. Cardiovasc Res. 2014; 102(2):249-57. DOI: 10.1093/cvr/cvu050. View

Ago T, Matsushima S, Kuroda J, Zablocki D, Kitazono T, Sadoshima J . The NADPH oxidase Nox4 and aging in the heart. Aging (Albany NY). 2011; 2(12):1012-6. PMC: 3034169. DOI: 10.18632/aging.100261. View

10.

BelAiba R, Djordjevic T, Petry A, Diemer K, Bonello S, Banfi B . NOX5 variants are functionally active in endothelial cells. Free Radic Biol Med. 2007; 42(4):446-59. DOI: 10.1016/j.freeradbiomed.2006.10.054. View

11.

Hordijk P . Regulation of NADPH oxidases: the role of Rac proteins. Circ Res. 2006; 98(4):453-62. DOI: 10.1161/01.RES.0000204727.46710.5e. View

12.

Bubb K, Drummond G, Figtree G . New opportunities for targeting redox dysregulation in cardiovascular disease. Cardiovasc Res. 2019; 116(3):532-544. DOI: 10.1093/cvr/cvz183. View

13.

Brandt M, Dorschmann H, Khraisat S, Knopp T, Ringen J, Kalinovic S . Telomere Shortening in Hypertensive Heart Disease Depends on Oxidative DNA Damage and Predicts Impaired Recovery of Cardiac Function in Heart Failure. Hypertension. 2022; 79(10):2173-2184. DOI: 10.1161/HYPERTENSIONAHA.121.18935. View

14.

Lopaschuk G, Karwi Q, Tian R, Wende A, Abel E . Cardiac Energy Metabolism in Heart Failure. Circ Res. 2021; 128(10):1487-1513. PMC: 8136750. DOI: 10.1161/CIRCRESAHA.121.318241. View

15.

Konior A, Schramm A, Czesnikiewicz-Guzik M, Guzik T . NADPH oxidases in vascular pathology. Antioxid Redox Signal. 2013; 20(17):2794-814. PMC: 4026218. DOI: 10.1089/ars.2013.5607. View

16.

Vendrov A, Vendrov K, Smith A, Yuan J, Sumida A, Robidoux J . NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease. Antioxid Redox Signal. 2015; 23(18):1389-409. PMC: 4692134. DOI: 10.1089/ars.2014.6221. View

17.

Jaquet V, Marcoux J, Forest E, Leidal K, McCormick S, Westermaier Y . NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action. Br J Pharmacol. 2011; 164(2b):507-20. PMC: 3188888. DOI: 10.1111/j.1476-5381.2011.01439.x. View

18.

Bertero E, Maack C . Metabolic remodelling in heart failure. Nat Rev Cardiol. 2018; 15(8):457-470. DOI: 10.1038/s41569-018-0044-6. View

19.

Xu Y, Pan Y, Wang X, Chen A, Tang X, Liu X . Knockdown of Salusin- Improves Cardiovascular Function in Myocardial Infarction-Induced Chronic Heart Failure Rats. Oxid Med Cell Longev. 2021; 2021:8896226. PMC: 8373485. DOI: 10.1155/2021/8896226. View

20.

Jandeleit-Dahm K . Endothelin in diabetes-associated atherosclerosis: opportunity 'NOX'. Cardiovasc Res. 2021; 117(4):987-989. DOI: 10.1093/cvr/cvab018. View