» Articles » PMID: 36407285

Effect of Stomach Motility on Food Hydrolysis and Gastric Emptying: Insight from Computational Models

Overview
Date 2022 Nov 21
PMID 36407285
Authors
Affiliations
Soon will be listed here.
Abstract

The peristaltic motion of stomach walls combines with the secretion of digestive enzymes to initiate the process that breaks down food. In this study, the mixing, breakdown, and emptying of a liquid meal containing protein is simulated in a model of a human stomach. In this model, pepsin, the gastric enzyme responsible for protein hydrolysis, is secreted from the proximal region of the stomach walls and allowed to react with the contents of the stomach. The velocities of the retropulsive jet induced by the peristaltic motion, the emptying rate, and the extent of hydrolysis are quantified for a control case as well as for three other cases with reduced motility of the stomach, which may result from conditions such as diabetes mellitus. This study quantifies the effect of stomach motility on the rate of food breakdown and its emptying into the duodenum and we correlate these observations with the mixing in the stomach induced by the wall motion.

Citing Articles

A novel compartmental approach for modeling stomach motility and gastric emptying.

Fernandes S, Kothare M, Mahmoudi B Comput Biol Med. 2024; 181:109035.

PMID: 39213708 PMC: 11493153. DOI: 10.1016/j.compbiomed.2024.109035.


Surface mapping of gastric motor functions using MRI: a comparative study between humans and rats.

Wang X, Alkaabi F, Choi M, Di Natale M, Scheven U, Noll D Am J Physiol Gastrointest Liver Physiol. 2024; 327(3):G345-G359.

PMID: 38915290 PMC: 11427095. DOI: 10.1152/ajpgi.00045.2024.


modelling of the effect of pyloric intervention procedures on gastric flow and emptying in a stomach with gastroparesis.

Kuhar S, Seo J, Pasricha P, Mittal R J R Soc Interface. 2024; 21(210):20230567.

PMID: 38263890 PMC: 10824103. DOI: 10.1098/rsif.2023.0567.

References
1.
Urbain J, Siegel J, Charkes N, Maurer A, Malmud L, Fisher R . The two-component stomach: effects of meal particle size on fundal and antral emptying. Eur J Nucl Med. 1989; 15(5):254-9. DOI: 10.1007/BF00257543. View

2.
Camilleri M, Bharucha A, Farrugia G . Epidemiology, mechanisms, and management of diabetic gastroparesis. Clin Gastroenterol Hepatol. 2010; 9(1):5-12. PMC: 3035159. DOI: 10.1016/j.cgh.2010.09.022. View

3.
Grover M, Farrugia G, Stanghellini V . Gastroparesis: a turning point in understanding and treatment. Gut. 2019; 68(12):2238-2250. PMC: 6874806. DOI: 10.1136/gutjnl-2019-318712. View

4.
Davis J, Ripley R . Postgastrectomy Syndromes and Nutritional Considerations Following Gastric Surgery. Surg Clin North Am. 2017; 97(2):277-293. DOI: 10.1016/j.suc.2016.11.005. View

5.
Schulze K . Imaging and modelling of digestion in the stomach and the duodenum. Neurogastroenterol Motil. 2006; 18(3):172-83. DOI: 10.1111/j.1365-2982.2006.00759.x. View