Skewed Fate and Hematopoiesis of CD34 HSPCs in Umbilical Cord Blood Amid the COVID-19 Pandemic

Overview

Journal iScience

Publisher Cell Press

Date 2022 Nov 21

PMID 36406860

Authors

Benjamin K Estep

Charles J Kuhlmann

Satoru Osuka

Gajendra W Suryavanshi

Yoshiko Nagaoka-Kamata

Ciearria N Samuel

Madison T Blucas

Chloe E Jepson

Paul A Goepfert

Masakazu Kamata

Affiliations

Soon will be listed here.

Abstract

Umbilical cord blood (UCB) is an irreplaceable source for hematopoietic stem progenitor cells (HSPCs). However, the effects of SARS-CoV-2 infection and COVID-19 vaccination on UCB phenotype, specifically the HSPCs therein, are currently unknown. We thus evaluated any effects of SARS-CoV-2 infection and/or COVID-19 vaccination from the mother on the fate and functionalities of HSPCs in the UCB. The numbers and frequencies of HSPCs in the UCB decreased significantly in donors with previous SARS-CoV-2 infection and more so with COVID-19 vaccination via the induction of apoptosis, likely mediated by IFN-γ-dependent pathways. Two independent hematopoiesis assays, a colony forming unit assay and a mouse humanization assay, revealed skewed hematopoiesis of HSPCs obtained from donors delivered from mothers with SARS-CoV-2 infection history. These results indicate that SARS-CoV-2 infection and COVID-19 vaccination impair the functionalities and survivability of HSPCs in the UCB, which would make unprecedented concerns on the future of HSPC-based therapies.

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